Prostaglandin H2 Causes Calcium Mobilization in Intact Human Platelets
It was originally suggested that thromboxane A2 (TxA2) production is a prerequisite for platelet activation induced by arachidonic acid (AA) addition. More recently, however, evidence has accumulated that suggests that, under the appropriate conditions, prostaglandin H2 (PGH2) can also play a role in the platelet activation process. In this regard, Needleman et al. (1976) have shown that when AA was added to washed platelets incubated with the thromboxane synthase inhibitor im-idazole (Needleman et al., 1976, 1977a,b; Moncada et al., 1976, 1977), thromboxane synthesis was blocked, but platelet aggregation was not inhibited (Needleman et al., 1977b). Based on these findings, they proposed that PGH2 is itself active in causing platelet aggregation.
KeywordsCalcium Mobilization Heptanoic Acid Thromboxane Synthetase Thromboxane Synthesis TxA2 Production
Unable to display preview. Download preview PDF.
- Brace, L.D., Venton, D.L., and Le Breton, G.C, 1982, Thromboxane A2/prostaglandin H2 mobilizes calcium in human blood platelets, Circulation [Suppl.] 64:1198.Google Scholar