Some Novel Aspects of the Function of Prostaglandin E2 in the Coronary Circulation
Recently, much work has centered on the effects and possible physiological and pathological importance of coronary prostacyclin synthesis (Fitzpatrick et al., 1978; Hyman et al., 1978; Needleman and Kaley, 1978; Dusting et al., 1979; Lefer et al., 1979; Aiken et al., 1980; Jugdutt et al., 1981). Prostacyclin, however, is not the only cyclooxygenase product that is produced in the coronary vasculature. In this context, recent work by Gerritsen and Printz (1981) has shown that PGE2 is produced in large coronary arteries, coronary micro vessels, and also in microvas-cular endothelial cells (Gerritsen and Cheli, 1984). Additionally, we have demonstrated that PGE2 has potent effects on coronary blood flow (Hintze and Kaley, 1977) and under special conditions may activate cardiac ventricular receptors, leading to reflex effects on the circulation in general (Hintze and Kaley, 1984). Furthermore, Jugdutt et al. (1981) have shown that infusions of PGE1 ameliorate some of the harmful consequences of ischemia on the myocardium. The purpose of this chapter is to review the effects of PGE2 on the myocardium and coronary circulation and to describe our own, more recent observations on the effects of PGE2 on blood flow distribution in the myocardium, on large coronary vessels in conscious dogs, and on the possible reflex regulation of circulatory function.
KeywordsArachidonic Acid Left Anterior Descend Coronary Blood Flow Coronary Circulation Circumflex Coronary Artery
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