Properties of Prostaglandin-Biosynthesizing Enzymes
The biosynthetic conversion of the esterified arachidonate in membrane lipids to the various eicosanoids can be divided into three stages. First, arachidonate must be released from tissue esters as the free acid. It can then react with one of the fatty acid oxygenases (the various lipoxygenases and cyclooxygenase are in this category) to form a hydroperoxy acid. In the third stage, the intermediate hydro-peroxy acid is chemically modified to furnish the leukotrienes, classical prosta-glandins, thromboxanes, and prostacyclin.
KeywordsOptimal Velocity Prostaglandin Endoperoxide Peroxy Acid Eicosanoid Biosynthesis Vesicular Gland
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- De Witt, D.L., and Smith, W.L., 1983, Purification of prostacyclin synthase from bovine aorta by immunoaffinity chromatography, J. Biol. Chem. 258:3285–3293.Google Scholar
- Marshall, P. J., Kulmacz, R. J., and Lands, W. E. M., 1984, Hydroperoxides, free radicals and prostaglandin biosynthesis, in: Oxygen Radicals in Chemistry and Biology (W. Bors, M. Saran, and D. Tait, eds.), Walter de Gruyter, Berlin, pp. 299–304.Google Scholar
- Ullrich, V., and Haurand, M., 1983, Thromboxane synthetase as a cytochrome P450 enzyme, in: Advances in Prostaglandin, Thromboxane, and Leukotriene Research, Vol. 11 (B. Samuelsson, R. Paoletti, and P. Ramwell, eds.), Raven Press, New York, pp. 105–110.Google Scholar