A Comparison of the Contractile Responses of Rodent and Human Pulmonary Vascular Segments to Eicosanoids
Eicosanoids such as thromboxanes (Txs) and leukotrienes (LTs) are powerful spas-mogens. The pulmonary hemodynamic actions of leukotrienes are complex. For example, in the isolated rat lung preparation, the perfusion pressure is increased by LTC4 in a dose-dependent manner, and this response is blocked by FPL-55712, a leukotriene receptor antagonist (Iacopino et al., 1983). However, in the closed-chest rat with an intact circulation, the intravenous administration of LTC4 produces a dose-dependent decrease in pulmonary artery pressure. We concluded that the direct action of LTC4 on the pulmonary vasculature in this preparation (Iacopino et al., 1984) is obscured by the concurrent decrease in cardiac output.
KeywordsPulmonary Artery Pulmonary Vein Contractile Response Venous Segment Pulmonary Vascular Smooth Muscle
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- Chand, N., and Altura, B.M., 1981, Endothelial cells and relaxation of vascular smooth muscle cells: Possible relevance to lipoxygenases and their significance in vascular diseases, Microcirculation 1:297–317.Google Scholar