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A Comparison of the Contractile Responses of Rodent and Human Pulmonary Vascular Segments to Eicosanoids

  • Yvonne T. Maddox
  • Cynthia M. Cunard
  • Peter W. Ramwell
  • Ron Shapiro
  • Akira Kawaguchi
  • Mitchell Goldman
  • Richard R. Lower
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)

Abstract

Eicosanoids such as thromboxanes (Txs) and leukotrienes (LTs) are powerful spas-mogens. The pulmonary hemodynamic actions of leukotrienes are complex. For example, in the isolated rat lung preparation, the perfusion pressure is increased by LTC4 in a dose-dependent manner, and this response is blocked by FPL-55712, a leukotriene receptor antagonist (Iacopino et al., 1983). However, in the closed-chest rat with an intact circulation, the intravenous administration of LTC4 produces a dose-dependent decrease in pulmonary artery pressure. We concluded that the direct action of LTC4 on the pulmonary vasculature in this preparation (Iacopino et al., 1984) is obscured by the concurrent decrease in cardiac output.

Keywords

Pulmonary Artery Pulmonary Vein Contractile Response Venous Segment Pulmonary Vascular Smooth Muscle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Chand, N., and Altura, B.M., 1981, Endothelial cells and relaxation of vascular smooth muscle cells: Possible relevance to lipoxygenases and their significance in vascular diseases, Microcirculation 1:297–317.Google Scholar
  2. Cramer, E.B., Pologe, L., Pawlowski, N.A., Cohn, A.A., and Scott, W.A., 1983, Leukotriene C promotes prostacyclin synthesis by human endothelial cells, Proc. Natl. Acad. Sci. U.S.A. 80:4109–4113.PubMedCrossRefGoogle Scholar
  3. De Mey, J.G., and Vanhoutte, P.M., 1982, Heterogeneous behavior of the canine arterial and venous wall: Importance of the endothelium, Circ. Res. 51:439–447.PubMedCrossRefGoogle Scholar
  4. Furchgott, R.F., 1983, Role of endothelium in responses of vascular smooth muscle, Circ. Res. 53:557–573.PubMedCrossRefGoogle Scholar
  5. Furchgott, R.F., and Zawadzki, J.V., 1980, The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine, Nature 288:373–376.PubMedCrossRefGoogle Scholar
  6. Griffith, T.M., Edwards, D.H., Lewis, M.J., Newby, A.C, and Henderson, A.H., 1984, The nature of the endothelium-derived vascular relaxant factor, Nature 308:645–647.PubMedCrossRefGoogle Scholar
  7. Hanna, C.J., Bach, M.K., Pare, P.D., and Schellenberg, R.R., 1981, Slow-reacting substances (leukotrienes) contract human airways and pulmonary vascular smooth muscle in vitro, Nature 290:343–344.PubMedCrossRefGoogle Scholar
  8. Iacopino, V.J., Fitzpatrick, T.M., Ramwell, P.W., Rose, J.C, and Kot, P.A., 1983, Cardiovascular responses to leukotrienes in the rat, J. Pharmacol. Exp. Ther. 227:244–247.PubMedGoogle Scholar
  9. Iacopino, V.J., Compton, S.K., Fitzpatrick, T.M., Ramwell, P.W., Rose, J.C, and Kot, P.A., 1984, Responses to leukotriene C4 in perfused rat lung, J. Pharmacol. Exp. Ther. 229:654–657.PubMedGoogle Scholar
  10. McDonald, J.W., Ali, M., Morgan, E., Towsend, E.R., and Cooper, J.D., 1983, Thromboxane synthesis by sources other than platelets in association with complement-induced pulmonary leu-kostasis and pulmonary hypertension in sheep. Circ. Res. 52:1–6.PubMedCrossRefGoogle Scholar
  11. Pomerantz, K., Maddox, Y., Maggi, F., Ramey, E., and Ramwell, P., 1980, Sex and hormonal modification of 6-keto-PGF release by rat aorta, Life Sci. 27:1233–1236.PubMedCrossRefGoogle Scholar
  12. Schellenberg, R.R., and Foster, A., 1984, Differential activity of leukotrienes upon human pulmonary vein and artery, Prostaglandins 27:475–482.PubMedCrossRefGoogle Scholar
  13. Smith, B.J., Ogletree, ML., Lefer, A.M., and Nicolaou, K.C, 1978, Antibodies which antagonise the effects of prostacyclin. Nature 274:64–65.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1985

Authors and Affiliations

  • Yvonne T. Maddox
    • 1
  • Cynthia M. Cunard
    • 1
  • Peter W. Ramwell
    • 1
  • Ron Shapiro
    • 2
  • Akira Kawaguchi
    • 2
  • Mitchell Goldman
    • 2
  • Richard R. Lower
    • 2
  1. 1.Department of Physiology and BiophysicsGeorgetown University Medical CenterUSA
  2. 2.Division of Cardiac SurgeryMedical College of VirginiaRichmondUSA

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