Regulatory Mechanisms in Prostacyclin-Blood Vessel Interactions

  • Babette B. Weksler
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)


The mechanisms governing prostaglandin production and action in vascular tissue are steadily becoming clarified. The former concept of a direct balance between vascular prostacyclin (PGI2) and platelet thromboxane (TxA2) in mediating vascular tone or hemostasis now appears simplistic and has been replaced. Current knowledge suggests instead a network of interactions among eicosanoid products of vascular cells, blood elements, and plasma factors (Fig. 1).


Cholesteryl Ester Rabbit Aorta Cholesteryl Ester Hydrolase Prostacyclin Production Platelet Thromboxane 
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Copyright information

© Springer Science+Business Media New York 1985

Authors and Affiliations

  • Babette B. Weksler
    • 1
  1. 1.Division of Hematology-Oncology, Department of MedicineCornell University Medical CollegeNew YorkUSA

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