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Regulatory Mechanisms in Prostacyclin-Blood Vessel Interactions

  • Babette B. Weksler
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)

Abstract

The mechanisms governing prostaglandin production and action in vascular tissue are steadily becoming clarified. The former concept of a direct balance between vascular prostacyclin (PGI2) and platelet thromboxane (TxA2) in mediating vascular tone or hemostasis now appears simplistic and has been replaced. Current knowledge suggests instead a network of interactions among eicosanoid products of vascular cells, blood elements, and plasma factors (Fig. 1).

Keywords

Cholesteryl Ester Rabbit Aorta Cholesteryl Ester Hydrolase Prostacyclin Production Platelet Thromboxane 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Boxer, L.A., Allen J.M., Schmidt, M., Yoder, M., Baehner, R.L., 1980, Inhibition of polymor-phonuclear leukocyte adherence by prostacyclin, J. Lab. Clin. Med. 95:672–678.PubMedGoogle Scholar
  2. Brotherton, A.F.A., and Hoak, J.C, 1983, Prostacyclin biosynthesis in cultured vascular endothelium is limited by deactivation of cyclooxygenase, J. Clin. Invest. 72:1255–1262.PubMedCrossRefGoogle Scholar
  3. Cramer, E.B., Pologe, L., Pawlowski, N.A., Cohn, Z.A., and Scott, W.B., 1983, Leukotriene C promotes prostacyclin synthesis by human endothelial cells, Proc. Natl. Acad. Sci. U.S.A. 80:4109–4113.PubMedCrossRefGoogle Scholar
  4. Defreyn, G., Deckmyn, H., and Vermylen, J., 1982, A thrombin synthetase inhibitor reorients endo-peroxide metabolism in whole blood towards prostacyclin and prostaglandin E2, Throm. Res. 26:389–400.CrossRefGoogle Scholar
  5. Eldor, A., Falcone, D.J., Hajjar, D.P., Minick, C.R., and Weksler, B.B., 1981, Recovery of prostacyclin production by de-endothelialized rabbit aorta. Critical role of neointimal smooth muscle cells. J. Clin. Invest. 67:735–741.PubMedCrossRefGoogle Scholar
  6. Eldor, A., Falcone, D.J., Hajjar, D.P., Minick, C.R., and Weksler, B.B., 1982, Diet-induced hypercholesterolemia inhibits the recovery of prostacyclin production by injured rabbit aorta, Am. J. Pathol. 107:186–190.PubMedGoogle Scholar
  7. Eldor, A., Fridman, R., Vlodavsky, I, Hyam, E., Fuks, Z., and Panet, A., 1984, Interferon enhances prostacyclin production by cultured vascular endothelial cells, J. Clin. Invest. 73:251–257.PubMedCrossRefGoogle Scholar
  8. Etingin, O., Hajjar, D. P., and Weksler, B. B., 1984, Hydrolytic metabolites of prostacyclin alter cholesteryl ester metabolism in arterial cells, Clin. Res. 32:473A.Google Scholar
  9. Fitzgerald, G.A., Brash, A.R., Oates, J.A., and Pedersen, A.K., 1983, Endogenous prostacyclin biosynthesis and platelet function during selective inhibition of thromboxane synthase in man, J. Clin. Invest. 72:1336–1343.PubMedCrossRefGoogle Scholar
  10. Gerritsen, M.E., and Cheli, C.D., 1983, Arachidonic acid and prostacyclin endoperoxide metabolism in isolated rabbit and coronary microvessels and isolated cultivated coronary microvessel endothelial cells, J. Clin. Invest. 72:1658–1671.PubMedCrossRefGoogle Scholar
  11. Goldsmith, J.C, Jafvert, C.T., Lollar, P., Owen, W.G., and Hoak, J.C, 1981, Prostacyclin release from cultured and ex vivobovine vascular endothelium, Lab. Invest. 45:191–197.PubMedGoogle Scholar
  12. Greenwald, J.E., Bianchine, J.R., and Wong, I.K., 1979, The production of the arachidonate metabolite HETE in vascular tissue, Nature 281:588–590.PubMedCrossRefGoogle Scholar
  13. Hajjar, D.P., Weksler, B.B., Falcone, D.J., Hefton, J.M., Tack-Goldman, K., and Minick, C.R., 1982, Prostacyclin modulates cholesteryl ester hydrolytic activity by its effect on cyclic adenosine monophosphate in rabbit aortic smooth muscle cells, J. Clin. Invest. 70:479–488.PubMedCrossRefGoogle Scholar
  14. Hajjar, D.P., and Weksler, B.B., 1983, Metabolic acitivity of cholesteryl esters in aortic smooth muscle cells is altered by prostaglandins I2 and E2, J. Lipid. Res. 24:1176–1185.PubMedGoogle Scholar
  15. Hoak, J. C, Fry, G. L., Czervionke, R. L., and Haycraft, D. L., 1984, Prostacyclin production in the isolated jugular vein segment, Clin. Res. 32:551A.Google Scholar
  16. Jaffe, E.A., and Weksler, B.B., 1979, Recovery of endothelial prostacyclin (PGI2) production after inhibition by low dose aspirin, J. Clin. Invest. 63:532–535.PubMedCrossRefGoogle Scholar
  17. Kent, R.S., Diedrich, S.L., and Whorton, A.R., 1983, Regulation of vascular prostaglandin synthesis by metabolites of arachidonic acid in perfused rabbit aorta, J. Clin. Invest. 72:455–465.PubMedCrossRefGoogle Scholar
  18. Kuo, P.T., Wilson, A.C, Goldtsein, R.C, and Schaub, R.G., 1984, Suppression of experimental atherosclerosis in rabbits by interferon-inducing agents, J. Am. Coll. Cardiol. 3:129–134.PubMedCrossRefGoogle Scholar
  19. Marcus, A.J., Safier, L.B., Ullman, H.L., Broekman, M.J., Islam, N., Oglilsby, T.D., and Gorman, R.R., 1984, 125,20-Dihydroxyicosatetraenoic acid. A new icosanoid synthesized by neutrophils from 12-S hydroxyicosatetraenoic acid produced by thrombin-or collagen-stimulated platelets, Proc. Natl. Acad. Sci. U.S.A. 81:903–907.PubMedCrossRefGoogle Scholar
  20. Marcus, A.J., Weksler, B.B., and Jaffe, E.A., 1978, Enzymatic conversion of prostaglandin endoperoxide H2 (PGH2) and arachidonic acid to prostacyclin by cultured human endothelial cells, J. Biol. Chem. 253:7138–7141.PubMedGoogle Scholar
  21. Rolland, P.H., Jouve, R., Pellegrin, E., Mercier, C, and Serradimigni, A., 1984, Alterations in prostacyclin and prostaglandin E2 production. Correlation with changes in human aortic atherosclerotic disease, Arteriosclerosis 4:70–78.PubMedCrossRefGoogle Scholar
  22. Salzman, P.M., Salmon, J.A., and Moncada, S., 1980, Prostacyclin and thromboxane A2 synthesis by rabbit pulmonary artery, J. Pharmacol. Exp. Ther. 215:240–247.PubMedGoogle Scholar
  23. Weksler, B.B., Knapp, J.M., and Jaffe, E.A., 1977, Prostacyclin (PGI2) synthesized by cultured endothelial cells modulates polymorphonuclear leukocyte function, Blood 50:287.Google Scholar
  24. Weksler, B. B., Knapp, J. M., and Tack-Goldman, K., 1979, Prostacyclin (PGI2) is destroyed by Superoxide produced by human polymorphonuclear leukocytes, Clin. Res. 27:466A.Google Scholar
  25. Weksler, B.B., Tack-Goldman, K., Subramanian, V.A., and Gray, W.A., Jr., 1985, Cumulative inhibitory effect of low-dose aspirin on vascular prostacyclin and platelet thromboxane production in patients with atherosclerosis, Circulation 71:332–340.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1985

Authors and Affiliations

  • Babette B. Weksler
    • 1
  1. 1.Division of Hematology-Oncology, Department of MedicineCornell University Medical CollegeNew YorkUSA

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