Prostaglandylinositol Cyclic Phosphate

An Antagonist to Cyclic AMP
  • Heinrich Karl Wasner
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)

Abstract

About 10 years ago studies were started in Earl Sutherland’s laboratory in search of a regulatory molecule with the ability to switch off the functions initiated by cAMP. I should like to dedicate this chapter to his memory. He would have been 70 years old in 1985.

Keywords

Hydrolysis Filtration Hydroxyl Carboxyl Carbonyl 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Begum, N., Tepperman, H., and Tepperman, J., 1983, Effect of indomethacin and prostaglandin E2 on insulin-generation of pyruvate dehydrogenase activator by liver and adipocyte plasma membrane, Diabetes 32:34a.Google Scholar
  2. Brass, E.P., Maureen, J.G., and Robertson, R.P., 1984, Inhibition of glucagon-stimulated hepatic glycogenolysis by E-series prostaglandins, FEBS Lett. 169:293–296.PubMedCrossRefGoogle Scholar
  3. Jarett, L., and Seals, J.R., 1979, Pyruvate dehydrogenase activation in adipocyte mitochondria by an insulin-generated mediator from muscle, Science 206:1407.PubMedCrossRefGoogle Scholar
  4. Lamer, J., Galasko, G., Cheng, K., De Paoli-Roach, A., Huang, L., Daggy, P., and Kellogg, J., 1979, Generation by insulin of a chemical mediator that controls protein phosphorylation and dephosphorylation, Science 206:1408–1410.CrossRefGoogle Scholar
  5. Seals, J.R., and Czech, M.P., 1980, Evidence that insulin activates an intrinsic plasma membrane protease in generating a secondary chemical mediator, J. Biol. Chem. 255:6529–6531.PubMedGoogle Scholar
  6. Steinberg, D., Vaughan, M., Nestel, P.J., Strand, O., and Bergstrom, S., 1964, Effects of the prostaglandins on hormone-uduced mobilization of free fatty acids, J. Clin. Invest. 43:1533.PubMedCrossRefGoogle Scholar
  7. Wasner, H. K., 1975a, On the biochemistry of a new hormone-messenger involving the alpha-receptor in rat liver, Communications 10th FEBS Meeting, Paris, Abstract 1367.Google Scholar
  8. Wasner, H.K., 1975b, Regulation of protein kinase and phosphoprotein phosphatase by cyclic AMP and cyclic AMP antagonist, FEBS Lett. 57:60–63.PubMedCrossRefGoogle Scholar
  9. Wasner, H.K., 1976, Preparation of a liver plasma membrane with an adrenalin responsive adenylyl cyclase after inhibition of prostaglandin synthesis by indomethacin, FEBS Lett. 72:127–130.PubMedCrossRefGoogle Scholar
  10. Wasner, H.K., 1980, yclic AMP antagonist—the hormone-messenger of insulin, Akt. Endokrinol. Stoffwechsel. 1:207–208.Google Scholar
  11. Wasner, H.K., 1981, Biosynthesis of cyclic AMP antagonist in hepatocytes from rats after adrenalin-or insulin-stimulation (isolation, purification and prostaglandin E-requirement for its synthesis), FEBS Lett. 133:260–264.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1985

Authors and Affiliations

  • Heinrich Karl Wasner
    • 1
  1. 1.Diabetes-ForschungsinstitutBiochemische AbteilungDüsseldorf 1West Germany

Personalised recommendations