Prostacyclin Can Inhibit DNA Synthesis in Vascular Smooth Muscle Cells
Vascular smooth muscle cell proliferation plays a pivotal role in physiological processes such as wound repair and in pathological processes such as atheromatous plaque formation. However, little is known about the mechanism by which DNA synthesis and cell growth are stimulated or regulated in vascular smooth muscle cells. In part, this lack of information is because of the lack of a suitable model system. In this regard, Ross (1971) was among the first to grow vascular smooth muscle cells in culture. It was observed that vascular smooth muscle cells, like other cells in culture, growth arrest at the G1/G0 interphase when deprived of serum or essential nutrients. It was subsequently determined that the vascular smooth muscle cell mitogenic factor in serum originated from platelets and has been appropriately termed platelet-derived growth factor (PDGF) (Ross et al., 1974).
KeywordsVascular Smooth Muscle Cell Adenylate Cyclase cAMP Level Cyclic Nucleotide Vascular Smooth Muscle Cell Proliferation
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