Postphospholipase Activation of Lipoxygenase/Leukotriene Systems
Once arachidonic acid is liberated by the action of acylhydrolases on cellular phos-pholipids or other esterified precursors, it can be metabolized either by the cycloox-ygenase or lipoxygenase pathways to a variety of biologically active compounds (Kuehl and Egan, 1980). Lipoxygenase metabolites including hydroperoxyeico-satetraenoic acids (HPETEs), hydroxyeicosatetraenoic acids (HETEs), and leuko-trienes appear to be involved in inflammatory processes (Samuelsson, 1983). Lipoxygenases in different cell types appear to exist in a relatively inactive site. An increasing number of studies indicate that the activation of different lipoxygenases can be accomplished by a diverse group of stimuli. It is the purpose of this chapter to discuss the research carried out in our laboratory on stimulators of mammalian lipoxygenases as well as to review the work of other investigators.
KeywordsArachidonic Acid Arachidonic Acid Metabolism Arachidonic Acid Metabolite Free Arachidonic Acid Arthus Reaction
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