Trials of Staphylococcal Protein A-Treated Plasma Infusions in Cancer Therapy: Clinical Effects and Implications for Mode of Action

  • F. Roy MacKintosh
  • Kim Bennett
  • Stephen W. Hall
Part of the Contemporary Topics in Immunobiology book series (CTI, volume 15)


Protein A, a cell wall protein of some strains of Staphylococcus aureus, was found to bind Fc receptors of some classes of IgG from many species (Forsgren and Sjoquist, 1966; Sjoquist, 1973). Its potential role in cancer therapy arose with demonstrations of the role of immunoglobulins as blocking factors (of cell-mediated cytotoxicity) in the serum of tumor-bearing animals (Hellström et al., 1969; Ankerst, 1971; Bansal et al., 1972, 1976). Some feel that the blocking factor is an antigen-antibody complex (Sjögren et al., 1971). Blocking activity could be demonstrated by in vitro cytotoxicity testing and could be removed by exposure of sera from tumor-bearing animals to S. aureus bearing protein A (Steele et al., 1974).


Acute Myeloid Leukemia Treated Plasma Ascitic Fluid Ovarian Cancer Patient Ovarian Cancer Cell Line 


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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • F. Roy MacKintosh
    • 1
  • Kim Bennett
    • 1
  • Stephen W. Hall
    • 1
  1. 1.Department of Internal MedicineUniversity of Nevada School of MedicineRenoUSA

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