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Clinical Significance and Nature of Circulating Immune Complexes in Melanoma Patients

  • Rishab K. Gupta
  • Donald L. Morton
Part of the Contemporary Topics in Immunobiology book series (CTI, volume 15)

Abstract

Most human malignant tissues express tumor antigens. Mechanisms whereby molecules that can act as tumor antigens may appear on the cell surface and make them autoantigenic have been proposed by Cochran (1978). It was proposed that neoantigens on tumor cells may appear by (1) reexpression of repressed molecules, (2) modification of existing molecules, (3) uncovering of masked molecules, and (4) deletion of existing molecules. There are many reports in the literature regarding the existence of certain tumor antigens that are immunogenic in the autologous and allogenic host. Though the biological and chemical natures of many of these antigens are not completely known, they are recognized as tumor-associated antigens (TAA). Humoral immune responses to TAA in melanoma patients have been summarized in recent reviews (Aryan, 1979; Old, 1981; Reisfeld and Ferrone, 1982).

Keywords

Immune Complex Tumor Burden Tumor Antigen Melanoma Patient Raji Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Rishab K. Gupta
    • 1
  • Donald L. Morton
    • 1
    • 2
  1. 1.John Wayne Cancer Clinic Division of Oncology Department of Surgery UCLA Medical SchoolUniversity of CaliforniaLos AngelesUSA
  2. 2.Armand Hammer Laboratories Division of Oncology Department of Surgery UCLA Medical SchoolUniversity of CaliforniaLos AngelesUSA

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