Platelet Kinetics

  • A. M. Peters
Part of the NATO ASI Series book series (NSSA, volume 88)


The subject of platelet kinetics can be conveniently considered under three separate headings: platelet distribution, analysis of platelet survival data, and platelet destruction or consumption; the latter is obviously closely related to platelet life-span.


Idiopathic Thrombocytopenic Purpura Time Activity Curve Platelet Destruction Platelet Survival Splenic Blood Flow 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    R. H. Aster and H. H. Jandl, Platelet sequestration in man: II immunological and clinical studies, J Clin Invest 43: 856–869 (1964).PubMedCrossRefGoogle Scholar
  2. 2.
    L. A. Harker, The kinetics of platelet production and destruction in man, Clin Haematol 6: 671 (1977).PubMedGoogle Scholar
  3. 3.
    A. duP. Heyns, M. G. Lotter, P. N. Badenhorst, O. R. Van Reenen, H. Pieters, P. C. Minnaar and F. P. Retief, Kinetics, distribution and sites of destruction of Indium-111 labeled human platelets, Br J Haematol 44: 269 (1980).PubMedCrossRefGoogle Scholar
  4. 4.
    I. Klonizakis, A. M. Peters, M. L. Fitzpatrick, M. J. Kensett, S. M. Lewis, J. P. Lavender, Radionuclide distribution following injection of 111-indium labeled platelets, Br J Haematol 46: 595 (1980).PubMedCrossRefGoogle Scholar
  5. 5.
    J. S. Robertson, M. K. Dewanjee, M. L. Brown, V. Fuster, J. J. Chesebro, Distribution and dosimetry of In-111-labeled platelets, Radiology 140: 169 (1981).PubMedGoogle Scholar
  6. 6.
    U. Scheffel, M. F. Tsan, T. G. Mitchell, E. E. Camargo, H. Braine, M. D. Ezekowitz, E. L. Nickoloff, R. Hill-Zobel, E. Murphy and P. A. McIntyre, Human platelets labeled with In-111–8 hydroxyquinoline: kinetics, distribution and estimates of radiation dose, J Nucl Med 23: 149 (1982).PubMedGoogle Scholar
  7. 7.
    A. M. Peters, I. Klonizakis, J. P. Lavender, S. M. Lewis, Use of Indium-111 labeled platelets to measure spleen function, Br J Haematol 46: 587 (1980).PubMedCrossRefGoogle Scholar
  8. 8.
    R. H. Aster, Pooling of platelets in the spleen: role in the pathogenesis of “hypersplenic” thrombocytopenia, J Clin Invest 45: 645 (1966).PubMedCrossRefGoogle Scholar
  9. 9.
    L. A. Harker and C. A. Finch, Thrombokinetics in man, J Clin Invest 48: 963 (1969).PubMedCrossRefGoogle Scholar
  10. 10.
    M. Freedman, N. Altzuler and S. Karpatkin, Presence of a nonsplenic platelet pool, Blood 50: 419 (1977).PubMedGoogle Scholar
  11. 11.
    L. Vilen, K. Freden, J. Kutti, Presence of a nonsplenic platelet pool in man, Scand J Haematol 24: 137 (1980).PubMedCrossRefGoogle Scholar
  12. 12.
    B. A. Martin, R. Dahlby, I. Nicholls, J. C. Hogg, Platelet sequestration in the lung with hemorrhagic shock and re-infusion in dogs, J Appl Physiol 50: 1306 (1981).PubMedGoogle Scholar
  13. 13.
    H. R. Bierman, K. H. Kelly, F. L. Cordes, R. L. Byron, J. A. Polhemus, S. Rapoport, The release of leukocytes and platelets from the pulmonary circulation by epinephrine, Blood 7: 683 (1952).PubMedGoogle Scholar
  14. 14.
    E. A. Hessel, G. Schmer, D. H. Dillard, Liver sequestration of platelets during hypothermia, J Surg Res 28: 23 (1980).PubMedCrossRefGoogle Scholar
  15. 15.
    A. duP. Heyns, M.G. Lotter, P.N. Badenhorst, H. Kotze, F.C. Killian, C. Herbst, O.R. Van Reenen and P.C. Minnaar, Kinetics and in vivo redistribution of Indium-111-labeled human platelets after intravenous protamine sulphate, Thromb Haemost 44: 65 (1980).PubMedGoogle Scholar
  16. 16.
    S. H. Saverymuttu, A. M. Peters, H. J. Danpure, H. J. Reavy, S. Osman, J. P. Lavender, Lung transit of Indium-111 labeled granulocytes: relationship to labelling techniques, Scand J Haematol 30: 151 (1983).PubMedCrossRefGoogle Scholar
  17. 17.
    R. H. Aster and J.H. Jandl, Platelet sequestration in man. I. Methods, J Clin Invest 43: 843 (1964).PubMedCrossRefGoogle Scholar
  18. 18.
    F. Vieras, Splenic uptake of In-111, J Nucl Med 16: 1205 (1975).PubMedGoogle Scholar
  19. 19.
    A. M. Peters, S. H. Saverymuttu, H. J. Reavy, R. N. Bell, J. P. Lavender, The kinetics of human autologous granulocytes labeled in plasma with Indium-111 tropolonate, submitted for publication.Google Scholar
  20. 20.
    A. M. Peters and J. P. Lavender, Factors controlling the intrasplenic transit of platelets, Eur J Clin Invest 12: 191 (1982).PubMedCrossRefGoogle Scholar
  21. 21.
    A. M. Peters, A. Rozkovec, R. N. Bell, K. A. Hallidie-Smith, J. F. Goodwin, J. P. Lavender, Platelets kinetics in congenital heart disease, Cardiovasc Dis 16: 391 (1982).Google Scholar
  22. 22.
    A. M. Peters and J. P. Lavender, Platelet kinetics with Indium-111 platelets: comparison with chromium-51 platelets, Sem Thromb Hemost 9: 100 (1983).CrossRefGoogle Scholar
  23. 23.
    R. Williams, R. E. Condon, H. S. Williams, L. M. Blendis, L. Kreel, Splenic blood flow in cirrhosis and portal hypertension, Clin Sci 34: 441 (1968).PubMedGoogle Scholar
  24. 24.
    A. M. Peters, M. J. Walport, R. N. Bell, J. P. Lavender, The measurement of splenic blood flow and intrasplenic platelet transit time in man using autologous Indium labeled platelets: a comparison of compartmental analysis with alternative analytical techniques, J Nucl Med.Google Scholar
  25. 25.
    A. M. Peters, M. J. Walport, K. B. Elkon, H. J. Reavy, P. P. Ferjencik, J. P. Lavender, G. R. V. Hughes, The comparative blood clearance kinetics of modified radiolabeled erythrocytes, Clin Sci.Google Scholar
  26. 26.
    L. Weiss, A scanning electron microscopic study of the spleen, Blood 43: 665 (1974).PubMedGoogle Scholar
  27. 27.
    N. R. Schulman, S. P. Watkins, S. B. Itscoitz and A. B. Students, Evidence that the spleen retains the youngest and hemostatically most effective platelets, Trans Assoc Am Phys 81: 302 (1968).Google Scholar
  28. 28.
    J. F. Martin, D. N. Slater, E. A. Trowbridge, Abnormal intrapulmonary platelet production: a possible cause of vascular and lung disease, Lancet 1: 793 (1983).PubMedCrossRefGoogle Scholar
  29. 29.
    C. B. Thompson, K. A. Eaton, S. M. Princiotta, C. A. Ruskin, C. R. Valeri, Size dependent platelet subpopulations: relationship to platelet volume to ultrastructure, enzymatic activity and function, Br J Haematol 50: 509 (1982).PubMedCrossRefGoogle Scholar
  30. 30.
    I. Branehog, Platelet kinetics in idiopathic thrombocytopaenic purpura before and at different times after splenectomy, Br J Haematol 29: 413 (1975).PubMedCrossRefGoogle Scholar
  31. 31.
    L. A. Harker, Thrombokinetics in idiopathic thrombocytopaenic purpura, Br J Haematol 19: 95 (1970).PubMedCrossRefGoogle Scholar
  32. 32.
    I. Branehog, A. Weinfeld, B. Roos, The exchangeable splenic platelet pool studied with epinephrine infusion in idiopathic thrombocytopaenic purpura and in patients with splenomegaly, Br J Haematol 25: 239 (1973).PubMedCrossRefGoogle Scholar
  33. 33.
    D. L. Williams, Improvement in quantitative data analysis by numerical deconvolution techniques, J Nucl Med 20: 568 (1979).PubMedGoogle Scholar
  34. 34.
    A. M. Peters, R. T. Mathie, M. J. Walport, H. J. Reavy, R. N. Bell, J. P. Lavender, Measurement of splenic blood flow in the anaesthetised dog using electromagnetic flowmetry and indium labeled platelets, Cardiovasc Res.Google Scholar
  35. 35.
    J. R. Stratton, B. L. Thiele, J. L. Ritchie, Platelet deposition on dacron aortic bifuriation grafts in man: quantitation with Indium-111 platelet imaging, Circulation 66: 1287 (1982).PubMedCrossRefGoogle Scholar
  36. 36.
    M. Goldman, H. C. Norcott, R. J. Hawker, Z. Drolc, C. N. McCollum, Platelet accumulation on mature dacron grafts in man, Br J Surg 69: S38 (1982).PubMedCrossRefGoogle Scholar
  37. 37.
    K. K. Wu and J. C. Hoak, A new method for the quantitative detection of platelet aggregates in patients with arterial insufficiency, Lancet 11: 924.Google Scholar
  38. 38.
    Y-C Chen and K. K. Wu, A comparison of methods for the study of platelet hyperfunction in thromboembolic disorders, Br J Haematol 46: 263 (1980).PubMedCrossRefGoogle Scholar
  39. 39.
    J. Mehta, P. Mehta, C. J. Pepine, Platelet aggregation in aortic and coronary venous blood in patients with and without coronary disease, Circulation 58: 881 (1978).PubMedGoogle Scholar
  40. 40.
    A. Kallinikos-Maniakas, Megakaryocytes and platelets in central venous and arterial blood, Acta Haematol 42: 330 (1969).CrossRefGoogle Scholar
  41. 41.
    S. T. Chandler, J. A. C. Buckels, Z. Drolc, R. J. Hawker, A. D. Barnes, C. N. McCollum, A bedside technique for the diagnosis of acute rejection in renal transplants using In-111-platelets, in: “Proceedings of the Third World Congress of Nuclear Medicine and Radiology”, C. Raynaud ed., 1575–1578, Perganon Press, Paris (1982).Google Scholar
  42. 42.
    E. A. Murphy and E. A. Francis, The estimation of blood platelet survival II. The multiple hit model, Thromb Diath Haemorrh 25: 53 (1971).PubMedGoogle Scholar
  43. 43.
    J. N. Mills, The life span of the erythrocyte, J Physiol 105: 16P (1946).Google Scholar
  44. 44.
    A. C. Dornhorst, The interpretation of red cell survival curves, Blood 6: 1284 (1961).Google Scholar
  45. 45.
    International Committee for Standardization in Haematology, Recommended methods for radioisotope platelet survival studies, Blood 50: 1137 (1977).Google Scholar
  46. 46.
    E. A. Trowbridge and J. F. Martin, A biological approach to the platelet survival curve with criticism of previous interpretations, Phys Med Biol.Google Scholar
  47. 47.
    E. Dassin, Y. Najean, O. Poirier, P. Passa and D. Bensoussan, In vivo platelet kinetics in 31 diabetic patients: Correlation with the degree of vascular impairment, Thromb Haemost 40:83 (1978).PubMedGoogle Scholar
  48. 48.
    S. R. Hanson, S. J. Slichter, L. A. Harker, The platelet requirement for normal haemostasis in man, Thromb Haemost 50: 189 (1983).Google Scholar
  49. 49.
    L. A. Harker, S. R. Hanson, T. R. Kirkman, Experimental arterial thrombembolism in baboons, J Clin Invest 64: 559 (1979).PubMedCrossRefGoogle Scholar
  50. 50.
    H. K. Watson and C. A. Ludlam, Survival of In-111 platelet subpopulations of varying density in normal and postsplenectomised subjects, Thromb Haemost 50: 213 (1983).Google Scholar
  51. 51.
    R. J. Hawker, C. E. Hall, M. Goldman, C. N. McCollum, In-111 loss from platelets by in-vitro and ex-vivo manipulation, in: P. Cox ed., Mastinus and Nijhoff, Netherlands.Google Scholar
  52. 52.
    D. J. Doyle, C. N. Chesterman, J. F. Cade, J. R. McGready, G. L. Rennie, F. J. Morgan, Plasma concentration of platelet specific proteins correlated with platelet survival, Blood 55: 82 (1980).PubMedGoogle Scholar
  53. 53.
    J. Y. Leung, J. Dykes, M. Goldman, R. J. Hawker, C. N. McCollum, How should platelet survival be measured? Thromb Haemost 50: 217 (1983).Google Scholar
  54. 54.
    A. duP. Heyns, M. G. Lotter, P. N. Badenhorst, 0. R. Van Reenen, H. Pieters, P. C. Minnaar, Kinetics and fate of Indium-111-oxine labeled platelets in asplenic subjects, Thromb Haemost 44: 100 (1980).Google Scholar
  55. 55.
    A. M. Peters, I. Klonizakis, J. P. Lavender, S. M. Lewis, Elution of Indium-111 from reticuloendothelial cells, J Clin Pathol 35: 507 (1982).PubMedCrossRefGoogle Scholar
  56. 56.
    B. K. Gunson, C. E. Hall, R. J. Hawker, W. A. Jurewicz, Extravasation of Indium-111 labeled platelets, Thromb Hemost 50: 15 (1983).Google Scholar
  57. 57.
    R. H. Aster, Studies of the fate of platelets in rats and man, Blood 34: 117 (1969).PubMedGoogle Scholar
  58. 58.
    C. A. Ries and D. C. Price, Cr-51 platelet kinetics in thrombocytopaenia: correlation between splenic sequestration of platelets and response to splenectomy, Ann Intern Med 80: 702 (1974).PubMedGoogle Scholar
  59. 59.
    A. duP. Heyns, M. G. Lotter, H. Pieters, F. H. Pauw, P. N. Badenhorst, P. Wessels, P. C. Minnaar, A quantitative study of Indium-111-oxine platelet kinetics in acute and chronic renal transplant rejection, Clin Nephrol 18: 174 (1982).PubMedGoogle Scholar
  60. 60.
    A. duP. Heyns, M. G. Lotter, H. F. Kotze, H. Pieters, P. Wessels, Quantification of in vivo distribution of platelets labeled with Indium-111 oxine, J Nucl Med 23: 943 (1982).PubMedGoogle Scholar
  61. 61.
    R. J. Hawker, C. E. Hall, B. K. Gunson, S. T. Chandler, J. D. Kelly, Distribution of 114m-In labeled platelets: implications to radiation dosimetry and mechanism of platelet destruction, Thromb Haemost, 50: 38 (1983).Google Scholar
  62. 62.
    U. Scheffel, R. Hill-Zobel, M. F. Tsan, Quantification of in vivo distribution of platelets labeled with indium-111-oxine, J Nucl Med 23: 944 (1982).Google Scholar
  63. 63.
    R. H. Aster and W. R. Keene, Sites of platelet destruction in idiopathic thrombocytopenic purpura, Br J Haematol 16: 61 (1969).PubMedCrossRefGoogle Scholar
  64. 64.
    P. J. Toghill, S. Green, R. Ferguson, Platelet dynamics in chronic liver disease with special reference to the role of the spleen, J Clin Pathol 30: 367 (1977).PubMedCrossRefGoogle Scholar
  65. 65.
    Y. Najean and N. Ardaillou, The sequestration sites of platelets in idiopathic thrombocytopenic purpura: its correlation with the results of splenectomy, Br J Haematol 21: 153 (1971).PubMedCrossRefGoogle Scholar
  66. 66.
    M. Kotilainen, Platelet kinetics in normal subjects and in haematological disorders, with special reference to thrombocytopenia and the role of the spleen, Scand J Haematol, supplement 5 (1969).Google Scholar
  67. 67.
    A. P. Heyns, M. G. Lotter, P. N. Badenhorst, F. deKock, H. Pieters, C. Herbst, O. R. Van Reenen, H. Kotze, P. C. Minnaar, Kinetics and sites of destruction of 111-indium oxine labeled platelets in idiopathic thrombocytopenic purpura: a quantitative study, Am J Haematol 12: 167 (1982).CrossRefGoogle Scholar
  68. 68.
    H. H. Davis, W. A. Heaton, B. A. Siegel, C. J. Mathias, J. H. Joist, L. A. Sherman, M. J. Welch, Scintigraphic detection of arteriosclerotic lesions and venous thrombi in man by Indium-111 labeled autologous platelets, Lancet 1: 1185 (1978).PubMedCrossRefGoogle Scholar
  69. 69.
    A. Fenech, A. Nicholls, F. W. Smith, Indium labeled platelets in the diagnosis of renal transplant rejection: preliminary findings, Br J Radiol 54: 325 (1981).PubMedCrossRefGoogle Scholar
  70. 70.
    N. Smith, S. Chandler, R. J. Hawker, L. M. Hawker, A. D. Barnes, Indium labeled autologous platelets as diagnostic aid after renal transplantation, Lancet 11: 1241 (1979).CrossRefGoogle Scholar
  71. 71.
    C. Leithner, H. Sinzinger, M. Schwarz, Treatment of chronic kidney transplant rejection with prostacyclin; reduction of platelet deposition in the transplant, prolongation of platelet survival and improvement of transplant function, Prostaglandins 22: 783 (1981).PubMedCrossRefGoogle Scholar
  72. 72.
    M. D. Trip, M. R. Hardeman, F. A. Van Royen, C. A. Viser and J. Vreeken, Accumulation of In-111 labeled thrombocytes in left ventricular and aortic aneurysms, Thromb Haemost 50: 334 (1983).Google Scholar
  73. 73.
    H. Pieters, A. duP. Heyns, P. Wessels, M. G. Lotter, M. Locke, P.N. Badenhorst, Kinetics and Indium-111 oxinate labeled platelets in familial hypercholesterolaemia, Thromb Haemost 50: 137 (1983).Google Scholar
  74. 74.
    M. Goldman, H. C. Norcott, R. J. Hawker, C. Hail, Z. Drolc and C. N. McCollum, Femoropopliteal by-pass grafts - an isotope technique allowing in vivo comparison of thrombogenicity, Br J Surg 69: 380 (1982).PubMedCrossRefGoogle Scholar
  75. 75.
    W. J. Powers and B. A. Siegel, Thrombus imaging with Indium-111 platelets, Sem Thromb Haemost 9: 115 (1983).CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • A. M. Peters
    • 1
    • 2
  1. 1.Medical DivisionGlaxo Group Research LtdWare, HertfordshireUK
  2. 2.Department of Diagnostic RadiologyHammersmith HospitalLondonUK

Personalised recommendations