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Evaluation of Animal Models Using in-111-Labeled Platelets

  • Chapter
Radiolabeled Cellular Blood Elements

Part of the book series: NATO ASI Series ((NSSA,volume 88))

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Abstract

Animal models continue to be important for studying many diseases, some of which include vascular and cellular related phenomena. To better elucidate the parameters involved, radiolabeled blood components were employed for determining total blood volume (1), plasma volume (2) cell kinetics (4) and the detection of cellular-mediated disorders such as thrombosis (5) and abscessed tissue (6). As more information about vascular disorders is collected, the roles of platelets and leukocytes are more defined and have been described as participating in the regulation of prostaglandin production and thereby maintaining vascular integrity; the process of joint inflammation; and other subtle, less well-defined roles in atherosclerosis, cerebrovascular disease, and myocardial infarction.

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Authors and Affiliations

  1. The Edward Mallinckrodt Institute of Radiology, Washington University, St. Louis, MO, 63110, USA

    Carla Z. Mathias & Michael J. Welch

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  1. Carla Z. Mathias
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  1. Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA

    M. L. Thakur (Editor, and the ASI Director) (Editor, and the ASI Director)

  2. Yale University School of Medicine, New Haven, Connecticut, USA

    M. D. Ezikowitz

  3. University of Amsterdam, Amsterdam, The Netherlands

    M. R. Hardeman

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© 1985 Plenum Press, New York

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Mathias, C.Z., Welch, M.J. (1985). Evaluation of Animal Models Using in-111-Labeled Platelets. In: Thakur, M.L., Ezikowitz, M.D., Hardeman, M.R. (eds) Radiolabeled Cellular Blood Elements. NATO ASI Series, vol 88. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4922-8_6

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