Evaluation of Animal Models Using in-111-Labeled Platelets

  • Carla Z. Mathias
  • Michael J. Welch
Part of the NATO ASI Series book series (NSSA, volume 88)


Animal models continue to be important for studying many diseases, some of which include vascular and cellular related phenomena. To better elucidate the parameters involved, radiolabeled blood components were employed for determining total blood volume (1), plasma volume (2) cell kinetics (4) and the detection of cellular-mediated disorders such as thrombosis (5) and abscessed tissue (6). As more information about vascular disorders is collected, the roles of platelets and leukocytes are more defined and have been described as participating in the regulation of prostaglandin production and thereby maintaining vascular integrity; the process of joint inflammation; and other subtle, less well-defined roles in atherosclerosis, cerebrovascular disease, and myocardial infarction.


Nonhuman Primate Release Reaction Platelet Deposition Prostaglandin Endoperoxide Autologous Platelet 
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  1. 1.
    R. Wennesland, E. Brown, J. Hopper, Red cell, plasma, and blood volume in healthy men measured by radiochromium (Cr-51) cell tagging and hematocrit: influence of age, somatotype, and habits of physical activity on the variance of regression of volumes to height and weight combined, J Clin Invest 38: 1065 (1959).PubMedGoogle Scholar
  2. 2.
    P. J. Hurley, Red cell and plasma volumes in normal adults, J Nucl Med 16: 46 (1974).Google Scholar
  3. 3.
    W. A. Heaton, H. H. Davis, M. J. Welch, C. J. Mathias, J. H. Joist, L. A. Sherman, B. A. Siegel, Indium-Ill: new radionuclide label for studying human platelet kinetics, Br J Haematol 42: 613 (1979).PubMedGoogle Scholar
  4. 4.
    A. Heyns, M. G. Lotter, P. N. Badenhorst, 0. R. vanReenen, H. Pieters, P. C. Minnaar, F. P. Retief, Kinetics, distribution, and sites of destruction of 111-Indium-labeled human platelets, Br J. Haematol 44: 269 (1980).PubMedGoogle Scholar
  5. 5.
    D. A. Goodwin, J. T. Bushberg, B. U. Doherty, M. J. Lipton, F. K. Conley, C. J. Diamenti, C. F. Meares, Indium-ill-labeled autologous platelets for location of vascular thrombi in humans, J Nucl Med 19: 626 (1978).PubMedGoogle Scholar
  6. 6.
    M. L. Thakur, R. E. Coleman, M. J. Welch, Indium-111-labeled leukocytes for the localization of abcesses: preparation, analysis, tissue distribution and comparison with Gallium67-citrate in dogs, J Lab Clin Med 89: 217 (1977).PubMedGoogle Scholar
  7. 7.
    U. Scheffel, P. A. McIntyre, B. Evatt, J. A. Dvornisky, T. K. Natarajan, D. R. Bolling, E. A. Murphy, Evaluation of Indium-111 as a new high-photon yield gamma-emitting “physiological” platelet label, Johns Hopkins Med J 140: 285 (1977).PubMedGoogle Scholar
  8. 8.
    M. L. Thakur, M. J. Welch, H. J. Joist, R. E. Coleman, Indium-111-labeled platelets: studies on preparation and evaluation of in vitro and in vivo functions, Thromb Res 9: 345 (1976).PubMedGoogle Scholar
  9. 9.
    J. G. McAfee and M. L. Thakur, Survey of radioactive agents for in vitro labeling of phagocytic leukocytes, J Nucl Med 17: 480 (1976).PubMedGoogle Scholar
  10. 10.
    C. J. Mathias, W. A. Heaton, M. J. Welch, P. G. Douglas, J. D. Kelly, Comparison of In-111-oxine and In-111-acetylacetone for the labeling of cells: in vivo and in vitro biological testing, Int J Appl Radiat Isot 32: 651 (1981).PubMedGoogle Scholar
  11. 11.
    H. Sinn and D. J. Silvester, Simplified cell label with Indium-111-acetylacetone, Br J Radiol 52: 758 (1979).PubMedGoogle Scholar
  12. 12.
    M. K. Dewanjee, S. A. Rao, P. Didisheim, Indium-111-tropolone, new high-affinity platelet label: preparation and evaluation of labeling parameters, J Nucl Med 22: 981 (1981).PubMedGoogle Scholar
  13. 13.
    H. J. Danpure, S. Osman, F. Brady, The labeling of blood cells in plasma with In-111-tropolonate, Br J Radiol 55: 247 (1982).PubMedGoogle Scholar
  14. 14.
    M. L. Thakur and M. J. Barry, Preparation and evaluation of a new Indium-111 agent for efficient labeling of human platelets in plasma, J Lab Cmpds Radiopharm 19: 1410 (1982).Google Scholar
  15. 15.
    G. V. R. Born, Jr., Proceedings of the British Institute of Radiology. Cell labeling with gamma-emitting radionuclides for in vivo study, Brit J Radiol 53: 922 (1980).Google Scholar
  16. 16.
    R. P. Grimley, E. Rafimi, R. J. Hawker, Z. Drole, Imaging of 111-In-labelled platelets - a new method for the diagnosis of deep vein thrombosis, Br J Surg 68: 714 (1981).PubMedGoogle Scholar
  17. 17.
    A. French, J. K. Hussey, F. W. Smith, P. 0. Dendy, B. Bennett, A. S. Douglas, Diagnosis of deep vein thrombosis using autologous Indium-111-labeled platelets, Br Med J 282: 1020 (1981).Google Scholar
  18. 18.
    H. H. Davis, B. A. Siegel, J. H. Joist, W. A. Heaton, C. J. Mathias, L. A. Sherman, M. J. Welch, Scintigraphic detection of atherosclerotic lesions and venous thrombi in man with Indium-111-labeled autologous platelets, Lancet 1: 1185 (1978).PubMedGoogle Scholar
  19. 19.
    H. H. Davis and M. J. Welch, Radioisotopic detection of arterial thrombi, in: “Venous and Arterial Thrombosis: Pathogenesis, Diagnosis, Prevention, and Therapy,” J. H. Joist and L. A. Sherman, eds., p 295, Grune and Stratton, New York (1979).Google Scholar
  20. 20.
    S. R. Bergmann, R. A. Lerch, C. J. Mathias, B. E. Sobel, M. J. Welch, Non-invasive detection of coronary thrombi with In-111-platelets, J Nucl Med 24: 130 (1983).PubMedGoogle Scholar
  21. 21.
    M. D. Ezekowitz, E. 0. Smith, A. C. Cox, F. B. Taylor, Failure of aspirin to prevent incorporation of In-111-labeled platelets into cardiac thrombi in man, Lancet 440 (1981).Google Scholar
  22. 21.
    M. D. Ezekowitz, E. 0. Smith, A. C. Cox, F. B. Taylor, Failure of aspirin to prevent incorporation of In-111-labeled platelets into cardiac thrombi in man, Lancet 440 (1981).Google Scholar
  23. 23.
    J. Megerman, J. T. Christenson, K. C. Hanel, H. W. Strauss, W M. Abott, Imaging vascular grafts in vivo with Indium-111labeled platelets, Ann Surg 198: 178 (1983).PubMedGoogle Scholar
  24. 24.
    A. L. Riba, M. L. Thakur, A. Gottschalk, B. L. Zaret, Imaging experimental coronary artery thrombosis with In-111platelets, Circulation 60: 767 (1979).PubMedGoogle Scholar
  25. 25.
    W. J. Powers, B. A. Seigel, H. H. Davis, C. J. Mathias, H. B. Clark, M. J. Welch, Evaluation of cerebrovascular disease with Indium-111-platelet scintigraphy, Neurology 32: 939 (1982).Google Scholar
  26. 26.
    K. D. Schwartz and M. Kruger, Improvement in labeling erythrocytes with Tc-99m-pertechnetate, J Nucl Med 12: 323 (1977).Google Scholar
  27. 27.
    W. J. Powers, C. J. Mathias, K. T. Hopkins, B. A. Siegel M. J. Welch, Dual radiotracer technique for improved scintigraphic detection of thrombi, in: “Nuclear Medicine and Biology,” vol 1., C. Raynaud, ed., p 1163, Pergamon Press, Paris (1982).Google Scholar
  28. 28.
    C. B. Sutherland, M. E. King, S. J. Peerless, W. C. Begina, G. W. Brown, M. J. Chamberlain, Platelet interaction within giant intracranial aneurysms, J Neurosurg 56: 53 (1982).PubMedGoogle Scholar
  29. 29.
    P. N. Walsh, Collagen-platelet interaction in coagulation, hemostases and thrombosis, in “Platelets and Thrombosis,” D. C. B. Mills and F. I. Pareti, eds., p 125, Academic Press, New York (1977).Google Scholar
  30. 30.
    G. A. Jamieson, Interaction of platelets and collagen, in: “Platelets: Production, Function, Transfusion, and Storage,” M. G. Baldini and S. Ebbe, eds., p 171, Grune and Stratton, New York (1974).Google Scholar
  31. 31.
    J. F. Mustard, S. Moore, M. A. Packham, R. L. Kinlough-Rathbone, Platelets, thrombosis and atherosclerosis, Prog Biochem Pharmacol 14: 312 (1977).Google Scholar
  32. 32.
    S. Niewiarowski, E. Regoeczi, C. J. Stewart, A. Senyi, J. F. Mustard, Platelet interaction with polymerizing fibrin, J Clin Invest 51: 685 (1972).PubMedGoogle Scholar
  33. 33.
    S. Niewiarowski and C. J. Steward, Interaction of blood cells with fibrinogen and polymerizing fibrin, in: “Platelets: Multidisciplinary Approach,” G. Gaetano and S. Garottini, eds., p 131, Raven Press, New York (1978).Google Scholar
  34. 34.
    J. Vermylen, Physiology of haemostasis, in: “Platelets: Multidisciplinary Approach,” G. Gaetano and S. Garottini, eds., p 3, Raven Press, New York (1978).Google Scholar
  35. 35.
    U. Hedner and I. M. Nilsson, The role of fibrinolysis, clinics in haematology 10: 327 (1981).Google Scholar
  36. 36.
    R. G. MacFarlane, Haemostasis, in: “Human Blood Coagulation, Haemostasis and Thrombosis,” R. Briggs, ed., p 543, Blackwell Scientific Publications, London (1972).Google Scholar
  37. 37.
    S. Moncada and J. R. Vane, Arachidonic acid metabolites and the interactions between platelets and blood vessel walls, New Engl J Med 300: 1142 (1979).PubMedGoogle Scholar
  38. 38.
    C. Tsao, Vascular substances that modulate blood-to-vessel interactions, Artery 5: 246 (1979).Google Scholar
  39. 39.
    R. M. Nalbandian and R. L. Henry, Platelet-endothelial cell interactions, Seminars in Thrombosis and Haemostasis 5: 87 (1978).Google Scholar
  40. 40.
    S. Sherry, The role of the platelet in thrombosis, in: “Platelets and Thrombosis,” D. C. B. Mills and F. I. Pareti, eds., p 111, Academic Press, New York (1977).Google Scholar
  41. 41.
    D. C. B. Mills, Platelet aggregation and platelet nucleotide concentration in various species, in: “Haemostasis in Man and Other Animals,” R. G. Macfarlane, ed., p 99, Academic Press, London (1970).Google Scholar
  42. 42.
    Z. Sinakos and J. P. Caen, Platelet aggregation in mammalians (human, rat, rabbit, guinea-pig, horse, dog) a comparative study, Thromb Diath Haemorrh 17: 99 (1967).PubMedGoogle Scholar
  43. 43.
    V. P. Addonizio, EL. H. Edmunds, R. W. Colman, The function of monkey (M.Mulatta) platelets compared to platelets of pig, sheep, and man, J Lab clin Med 91: 989 (1978).PubMedGoogle Scholar
  44. 44.
    M. A. Packham and J. F. Mustard, Clinical pharmacology of platelets, Blood 50: 555 (1977).PubMedGoogle Scholar
  45. 45.
    J. R. Vane and S. Moncada, The anti-thrombotic effects of prostacyclin, Acta Med Scand (Suppl) 642: 11 (1980).Google Scholar
  46. 46.
    M. M. Guest, B. M. Daly, A. G. Ware, W. H. Seegers, A study of antifibrinolyisin activity in the plasma of various animal species, J Clin Invest 27: 785 (1948).Google Scholar
  47. 47.
    C. M. Hawkey, The relationship between blood coagulation and thrombosis and atherosclerosis in man, monkeys and carnivores, Thrombosis et Diathesis Haemorrhagica 31: 103 (1974).PubMedGoogle Scholar
  48. 48.
    H. V. Roohk, J. Pick, R. Hill, E. Hung, R. H. Bartlett, Kinetics of fibrinogen and platelet adherence to biomaterials, Trans Am Soc Artif Intern Organs 22: 1 (1976).PubMedGoogle Scholar
  49. 49.
    A. I. Schafer and R. I. Handen, The role of platelets in thrombotic and vascular disease, Prog Cardiovas Dis 22: 31 (1979).Google Scholar
  50. 50.
    W. J. Dodds, Platelet function in animals: Species specificities, in: “Platelets: A Multidisciplinary Approach,” G. Gaetano and S. Garattini, eds., p 45, Raven Press, New York (1976).Google Scholar
  51. 51.
    M. C. Scrutton and C. M. Egan, Divalent cation requirements for aggregation of human blood platelets and the role of the anti-coagulant, Thromb Res 14: 713 (1979).PubMedGoogle Scholar
  52. 52.
    R. H. Aster, Factors affecting the kinetics of isotopically-labeled platelets, in: “Platelet Kinetics,” J. M. Paulus, ed., p 5, North Holland Publishing Co., Amsterdam (1971).Google Scholar
  53. 53.
    M. Kien, F. A. Belamarich, D. Shepro, Effect of adenosine-related compounds on thrombocyte and platelet aggregation, Am J Physiol 221: 604 (1971).Google Scholar
  54. 54.
    M. J. Welch and C. J. Mathias, Platelet viability following Indium-111-oxine labeling in electrolyte solutions, in: “Indium-111-Labeled Neutrophils, Platelets, and Lymphocytes,” M. L. Thakur and A. Gottschalk, eds., p 93, Trivirum, New York (1980).Google Scholar
  55. 55.
    G. V. R. Born, Aggregation of haemostatic cells as an example of specialized cell function, in: “Platelet Aggregation and Drugs,” L. Caprino and E. C. Ross, eds., p 1, Academic Press, New York (1974).Google Scholar
  56. 56.
    J. F. Mustard and M. A. Packham, Factors influencing platelet function: adhesion, release, and aggregation, Pharmacol Rev 22: 97 (1970).PubMedGoogle Scholar
  57. 57.
    H. J. Weiss, Platelet physiology and abnormalities of platelet function, New Engl J Med 293: 531, (1975).PubMedGoogle Scholar
  58. 58.
    H. Holmsen, Are platelet shape, change, aggreagation, and release reaction tangeable manifestations of one basic platelet function, in: “Platelets: Production, Function, Transfusion, and Storage,” M. Baldini and S. Ebbe, eds., p 207, Grune and Stratton, New York (1974).Google Scholar
  59. 59.
    P. R. Roper-Drewinko, B. Drewinko, G. Corrigni, D. Johnston, K. P. McCredie, E. J. Freireuk, Standardization of platelet function test, Am J Hematol 11: 767 (1981).Google Scholar
  60. 60.
    H. J. Weiss, Pathophysiology and detection of clinically-significant platelet dysfunction, in: “Platelets: Production, Function, Transfusion and Storage,” M. G. Baldini and S. Ebbe, eds., p 253, Grune and Stratton, New York (1974).Google Scholar
  61. 61.
    D. C. MacMillan and A. K. Sim, A comparative study of platelet aggregation in man and laboratory animals, Thromb Diath Haemorrh 24: 385 (1970).PubMedGoogle Scholar
  62. 62.
    R. H. Harris, R. Nichols, J. W. Schmeling, P. W. Ramwell, Thromboxane A2 and the endoperoxides mediate canine platelet activation, Thromb Res 23: 521 (1981).PubMedGoogle Scholar
  63. 63.
    J. L. Wautier and J. P. Coen, Pharmacology of platelet suppressive agents, Sem Thromb Hemostasis 5: 293 (1979).Google Scholar
  64. 64.
    D. Ogston and B. Bennett, Surface-mediated reactions in the formation of thrombin, plasmin and Kallikrein, Br Med Bull 34: 107 (1978).PubMedGoogle Scholar
  65. 65.
    M. J. Gallimore, M. V. Nulkar, J. T. B. Shaw, A comparative study of the inhibitors of fibrinolysis in human, dog, and rabbit blood, Thrombpsos et Diathesis Haemorrhagica 14: 145 (1965).Google Scholar
  66. 66.
    C. M. Hawkey, Fibrinolysis in animals, in: “The Haemostatic Mechanism in Man and Other Animals,” R. G. MacFarlane, ed., p 143, Academic Press, London (1970).Google Scholar
  67. 67.
    R. G. Mason and M. S. Read, Some species differences in fibrinolysis and blood coagulation, J Biomed Mater Res 5: 121 (1971).PubMedGoogle Scholar
  68. 68.
    R. F. Doolittle, J. L. Omcley, D. M. Surgenor, Species differences in the interaction of thrombin and fibrinogen, J Biol Chem 237: 3123 (1962).PubMedGoogle Scholar
  69. 69.
    J. F. Smith, A. W. Sedar, C. M. Ingerman, M. J. Silver, Prostaglandin endoperoxides: platelet shape change, aggregation, and the release reaction, in: “Platelets and Thrombosis,” D. C. B. Mills and F. I. Pareti, eds., p 83, Academic Press, New York (1977).Google Scholar
  70. 70.
    M. Hamberg, B. Svensson, B. Samuelson, Thromboxanes new group of biologically-active compounds derived from prostaglandin endoperoxides, Proc Natl Acad Sci USA 72: 2994 (1975).PubMedGoogle Scholar
  71. 71.
    G. J. Roth, N. Stanford, J. W. Jacobs, P. W. Majerus, Acetylation of prostaglandin synthetase by aspirin purification and properties of acetylated proteins from sheep vesicular gland, Proc Natl Acad Sci USA 72: 3073 (1975).PubMedGoogle Scholar
  72. 72.
    J. B. Smith and A. L. Willis, Formation and release of prostaglandins by platelets in response to thrombin, Br J Pharmacol 40: 545 (1971).Google Scholar
  73. 73.
    S. S. Tang, M. M. Frozinovic, The effects of pCO2 pH on platelet shape, change and aggregation for human and rabbit platelet-rich plasma, Thromb Res 10: 135 (1977).PubMedGoogle Scholar
  74. 74.
    C. R. Cowan and F. C. Monkhouse, Studies on electrically-induced thrombosis and related phenomena, Cand J Physiol Pharmacol 44: 881 (1966).Google Scholar
  75. 75.
    P. Didisheim, Animal models useful in the study of thrombosis and antithrombotic agents, in: “Progress in Hemostasis and Thrombosis,” vol. 1, T. H. Spaet, ed., p 165, Grune and Stratton, New York (1976).Google Scholar
  76. 76.
    H. R. Baumgartner and C. Haudenschild, Adhesion of platelets to subendothelium, Ann NY Acad Sci 201: 22 (1972).PubMedGoogle Scholar
  77. 77.
    S. A. Johnson, Formation of thrombi on injured endothelium in mesenteric arterioles in guinea pig, Thrombosis et Diathesis Haemorrhagica (Suppl) 28: 65 (1968).Google Scholar
  78. 78.
    N. A. Kefalides and R. J. Wingler, The chemistry of glomerular basement membrane and its relation to collagen, Biochemistry 5: 702 (1966).PubMedGoogle Scholar
  79. 79.
    R. Ross and P. Bornstein, The elastic fiber, I. The separation and partial characterization of its macromolecular compoenents, J Cell Biol 40: 366 (1969).PubMedGoogle Scholar
  80. 80.
    H. R. Baumgartner, Platelet interaction with collagen fibrils in flowing blood, Thromb Haemost 37: 1 (1977).PubMedGoogle Scholar
  81. 81.
    G. Majno and G. E. Palade, Studies on inflammation. I. The effect of histamine and serotonin on vascular permeability. An electron microscopic study, J Biophys Biochem Cytol 11: 571 (1961).PubMedGoogle Scholar
  82. 82.
    M. I. Barnhart and S-T. Chen, Vessel wall models for studying interaction capabilities with blood platelets, Semin Thromb Hemostas 5: 112 (1978).Google Scholar
  83. 83.
    Z. D. Grossman, B. W. Wistow, J. G. McAfee, G. Subramanian, F. D. Thomas, R. W. Henderson, R. F. Rohner, M. L. Roskopf, Tc-99m-oxine and In-111-oxine-labeled platelets Part II Localization of experimentally induced vascular lesion, J Nucl Med 19: 488 (1978).PubMedGoogle Scholar
  84. 84.
    J. F. Harwig, S. S. Harwig, J. 0. Eichling, R. E. Colemen, M. J. Welch, I-123-Labeled soluble fibrin: preparation and comparison with other thrombus imaging agents, Int J Appl Radiat Isot 28: 157 (1976).Google Scholar
  85. 85.
    M. J. Welch and K. A. Krohn, Critical review of radiolabeled fibrinogen: its preparation and use, in: “Radiopharmaceuticals,” G. Subramanian, B. A. Rhodes, J. F. Cooper, V. J. Sodd, eds., p 493, Soc Nucl Med, New York (1975).Google Scholar
  86. 86.
    B. A. Rhodes, W. R. Bill, L. S. Malmud, M. E. Siegel, H. N. Wagner, Labeling and testing of urokinase and streptokinase: new tracers for the detection of thromoemboli, in: “Radio-pharmaceuticals and Labeled Compounds,” vol 2, Vienna, IAEA, p 163 (1973).Google Scholar
  87. 87.
    B. R. Persson and V. Kemper, Labeling and testing of 99m-Tcstreptokinase for the diagnosis of deep vein thrombosis, J Nucl Med 16: 474 (1977).Google Scholar
  88. 88.
    S. S. L. Harwig, J. F. Harwig, L. A. Sherman, R. E. Coleman, M. J. Welch, Radioiodinated plasminogen: an imaging agent for pre-existing thrombi, J Nucl Med 18: 42 (1977).PubMedGoogle Scholar
  89. 89.
    M. J. Welch, C. J. Mathias, B. A. Siegel, Clinical experience with Indium-111-labeled platelets, in: “Indium-111-Labeled Neutrophils, Platelets, and Lymphocytes,” M. L. Thakur and A. Gottschalk, eds., p 171, Trivirum, New York (1980).Google Scholar
  90. 90.
    A. M. White and S. Heptinstall, Contribution of platelets to thrombus formation, Br Med Bull 34: 123 (1978).PubMedGoogle Scholar
  91. 91.
    L. C. Knight, J. L. Primeau, B. A. Siegel, M. J. Welch, Comparison of In-111-labeled platelets and iodinated fibrinogen for the detection of deep vein thrombosis, J Nucl Med 19: 891 (1978).PubMedGoogle Scholar
  92. 92.
    S. I. Schwartz, Effects of electric environment on thrombosis, Clin Neurosurg 10: 291 (1962).Google Scholar
  93. 93.
    G. H. R. Rao, G. J. Johnson, R. K. Reddy, J. F. White, Rapid return of cyclo-oxygenase-active platelets in dogs after a single oral dose of aspirin, Prostaglandins 22: 761 (1981).PubMedGoogle Scholar
  94. 94.
    K. M. Moser, M. Grusan, E. E. Bartimo, In vivo and postmortem dissolution rates of pulmonary emboli and venous thrombi in the dog, Circulation 48:170 (1973).Google Scholar
  95. 95.
    G. Mclllmoyle, H. H. Davis, M. J. Welch, J. L. Primeau, L. A. Sherman, B. A. Siegel, Scintigraphic diagnosis of experimental pulmonary embolism with In-111-labeled platelets, J Nucl Med 18: 910 (1977).Google Scholar
  96. 96.
    R. S. Cotran, Ultrastructural studies of endothelial injury in the micro circulation with special reference to thrombosis, in: “Thrombosis,” S. Sherry, K. M. Brinkhous, E. Genton, J. M. Stengle, eds., p 437, National Academy of Science, Washington D.C. (1969).Google Scholar
  97. 97.
    B. C. Sheppard and J. E. French, Platelet adhesion in the rabbit abdominal aorta following the removal of the endothelium: a scanning and transmission electron microscopical study, Proc R Soc Lond (Biol) 176: 427 (1971).Google Scholar
  98. 98.
    L. A. Harker, R. Ross, J. A. Glomset, The role of endothelial cell injury and platelet response in atherogenesis, Thromb Haemost 39: 312 (1978).PubMedGoogle Scholar
  99. 99.
    W. H. Welch, The structure of white thrombi, Trans Path Soc Philadelphia 13: 281 (1887).Google Scholar
  100. 100.
    R. Ross and L. Harker, Hyperlipidemia and atherosclerosis. Chronic hyperlipidemia initiates and maintains lesions by endothelial cell desquamation and lipid accumulation, 193: 1094 (1976).Google Scholar
  101. 101.
    R. Ross, The arterial wall and atherosclerosis, Ann Rev Med 30: 1 (1979).PubMedGoogle Scholar
  102. 102.
    B. C. Bullock, N. D. M. Lehner, T. B. Clarkson, M. A. Feldner, W. D. Wagner, H. B. Lofland, Comparative primate atherosclerosis. I. Tissue cholesterol concentration and pathologic anatomy, Exp Mol Pathol 22: 151 (1975).PubMedGoogle Scholar
  103. 103.
    D. Steinberg, Research related to underlying mechanisms in atherosclerosis, Circulation 60: 1559 (1979).PubMedGoogle Scholar
  104. 104.
    H. Malmros and N. H. Sternby, Induction of atherosclerosis in dogs by a thiouracil-free semisynthetic diet containing cholesterol and hydrogenated coconut oil, Prog Biochem Pharmacol 4: 482 (1968).Google Scholar
  105. 105.
    S. C. Nam, W. M. Lee, J. Garmalyck, K. T. Lee, W. A. Thomas, Rapid production of advanced atherosclerosis in swine by a combination of endothelial injury and cholesterol feeding, Exp Med Pathol 28: 369 (1973).Google Scholar
  106. 106.
    J. C. Lewis, V. Fuster, B. A. Kottke, Spontaneous endothelial cell injury in the intimal cushions of atherosclerotic pigeons, Prog Biochem Pharmacol 14: 220 (1977).Google Scholar
  107. 107.
    H. M. Groves, R. L. Kinlough-Rathobone, M. Richardson, S. Moore, J. F. Mustard, Platelet interaction with damaged rabbit aorta, J Clin Lab Invest 40: 194 (1979).Google Scholar
  108. 108.
    R. W. Wissler and D. Vesselinovitch, Atherosclerosis in nonhuman primates, Adv Vet Sci Comp Med 21: 351 (1977).PubMedGoogle Scholar
  109. 109.
    R. Pick, P. J. Johnson, G. Glick, Deleterious effects of hypertension on the development of aortic and coronary atherosclerosis in stumptail macaques (Macaca speciosa) on an atherogenic diet, Circ Res 35: 472 (1974).PubMedGoogle Scholar
  110. 110.
    M. B. Stemerman and R. Ross, Experimental arteriosclerosis. I. Fibrous plaque formation in primates, an electron microscope study, J Exp Med 136: 769 (1972).PubMedGoogle Scholar
  111. 111.
    A. J. Honour, R. D. Carter, J. I. Mann, The effects of changes in the diet on lipid levels and platelet thrombus formation in living blood vessels, Br J Exp Path 50: 390 (1978).Google Scholar
  112. 112.
    W. D. Wagner and T. B. Clarkson, Comparative primate atherosclerosis. II. A biochemical study of lipids, calcium and collagen in atherotic arteries, Expe Mol Pathol 23: 96 (1975).Google Scholar
  113. 113.
    W. J. Powers, C. J. Mathias, M. J. Welch, L. A. Sherman, B. A. Siegel, T. B. Clarkson, Scintigraphic detection of platelet deposition in atherosclerotic macaques: a new model for investigation of antithrombotic drugs, Thromb Res 25: 137 (1982).PubMedGoogle Scholar
  114. 114.
    S. R. Bergmann, C. J. Mathias, B. E. Sobel, M. J. Welch, Evaluation of thrombolytic therapy in coronary artery thrombosis: scintigraphic detection with the use of In-111-labeled platelets, in: “Nuclear Medicine and Biology,” vol.1, C. Raynaud, ed., p 65, Pergamon Press, Paris (1982).Google Scholar
  115. 115.
    M. A. Dewood, J. Spores, R. Notske, L. T. Mouser, K. Burroughs, M. S. Galden, H. T. Lang, Prevalence of total coronary occlusion during the early hours of transmural myocardial infarction, New Engl J Med 303: 897 (1980).PubMedGoogle Scholar
  116. 116.
    L. R. Erhardt, T. Lundman, H. Millstedt, Incorporation of I-125-labeled fibrinogen into coronary arterial thrombi on acute myocardial infarction in man, Lancet 1: 387 (1973).PubMedGoogle Scholar
  117. 117.
    M. D. Ezekowitz, R. D. Burrow, P. W. Heath, T. Streitz, E. 0. Smelk, D. E. Parker, Diagnostic accuracy of Indium-111 platelet scintigraphy in identifying left ventricular thrombi, Am J Cardiol 51: 1712 (1983).PubMedGoogle Scholar
  118. 118.
    R. Kordenat and K. Kizidi, Experimental intracoronary thrombosis and selective in situ lysis by catheter technique, Am J Cardiol 30 (1972).Google Scholar
  119. 119.
    C. A. Ramirez, M. B. Stemerman, K. A. Isaacson, C. K. Colton, KI. A. Smith, R. S. Lees, Morphological and morphometric characterization of platelet adhesion to the exposed subendothelium of the rabbit thoracic aorta in vivo, Microvasc Res 21: 320 (1981).PubMedGoogle Scholar
  120. 120.
    R. H. Bourgain, The inhibitory effect of PGI2 (Prostacyclin) on white platelet arterial thrombus formation, Haemostasis 8: 117 (1979).PubMedGoogle Scholar
  121. 121.
    D. M. Creasy, M. Fallenfant, D. A. James, A. D. Dayan, Preliminary toxicity testing of prostacyclin, in: “Prostacyclin,” J. R. Vane and S. Bergstrom, eds., p 385, Raven Press, NY (1979).Google Scholar
  122. 122.
    H. Sinzinger, P. Clopath, K. Silberbauer, The effect of ballooning onminipeg aortic prostacyclin formation - a time course, Artery 1: 23 (1980).Google Scholar
  123. 123.
    S. M. M. Karim, P. G. Adarkan, Some pharmacological studies with prostacyclin in baboon and man, in: “Prostacyclin,” J. R. Vane and S. Berstrom, eds., p 419, Raven Press, NY (1979).Google Scholar
  124. 124.
    M. R. Buchanan, E. Dejana, M. Gent, J. F. Mustard, J. Hirsch, Enhanced platelet accumulation onto injured carotid arteries in rabbits after aspirin treatment, J Clin Invest 67: 503 (1981).PubMedGoogle Scholar
  125. 125.
    S. Jaeger and H. Berntsen, Deposition of human labeled platelets on damaged rabbit aorta before and after ingestion of acetylsalicylic acid, Haemostasis 8: 99 (1979).PubMedGoogle Scholar
  126. 126.
    B. Adelman, M. B. Slemmerman, D. Mennell, R. E. Hardin, The interaction of platelets with aortic subendothelium: inhibition of adhesion and secretion by Prostaglandin I-2, Blood 58: 198 (1981).PubMedGoogle Scholar
  127. 127.
    H. J. Weiss and V. T. Turitto, Prostacyclin (Prostaglandin I-2, PGI2) inhibits platelet adhesion and thrombus formation on subendothelium, Blood 53: 244 (1979).PubMedGoogle Scholar
  128. 128.
    R. J. Gryglewski, R. Korbut, A. Ocetkiewicz, Reversal of platelet aggregation by prostacyclin. Pharmacol Res Commun 10: 185 (1978).PubMedGoogle Scholar
  129. 129.
    M. Goldman, H. C. Norcott, R. J. Hawker, Z. Drolc, C. N. McCollum, Platelet accumulation on mature dacron grafts in man, Br J Surg 69 (Suppl) S38 (1982).PubMedGoogle Scholar
  130. 130.
    S. Berger, E. W. Salzman, E. W. Merrill, P. S. Wong, The reaction of platelets with prosthetic surfaces, in: “Platelets: Production, Function, Transfusion, and Storage,” M. G. Baldini and S. Ebbe, eds., p 299, Grune and Stratton, New York (1974).Google Scholar
  131. 131.
    C. D. Forbes and C. R. Prentice, Thrombus formation and artificial surfaces, Br Med Bull 34: 201 (1978).PubMedGoogle Scholar
  132. 132.
    V. Fuster, M. K. Dewanjee, M. P. Kaye, M. Josa, M. P. Metke, J. H. Chesebro, Noninvasive radioisotopic technique for detection of platelet deposition in coronary artery bypass grafts in dogs and its reduction with platelet inhibitors, Circulation 60: 1508 (1979).PubMedGoogle Scholar
  133. 133.
    J. T. Christensen, J. Megerman, K. C. Hanel, G. J. L’Italien, H. W. Strauss, W. M. Abbott, The effect of blood flow rates on platelets deposition in PTFE arterial bypass grafts, Trans Am Soc Artif Intern Organs 27: 188 (1981).Google Scholar
  134. 134.
    J. L. Ritchie, J. R. Stratton, B. Thiele, G. W. Hamilton, L. N. Warrick, T. W. Huang, L. A. Harker, In-111 platelet imaging for detection of platelet deposition in abdominal aneurysms and prosthetic arterial grafts, Am J CardioL 47: 882 (1981).PubMedGoogle Scholar
  135. 135.
    G. P. Clagett, M. Robinowitz, Y. Maddox, J. M. Langloss, P. W. Ramwell, The antithrombotic nature of vascular prosthetic pseudointima, Surgery 91: 87 (1982).PubMedGoogle Scholar
  136. 136.
    P. Hagen, S. Wang, E. M. Mikat, D. B. Hackel, Antiplatelet therapy reduces aortic intimal hyperplasia distal to small diameter vascular prosthesis (PTFE) in nonhuman primates, Ann Surg 195: 328 (1982).PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Carla Z. Mathias
    • 1
  • Michael J. Welch
    • 1
  1. 1.The Edward Mallinckrodt Institute of RadiologyWashington UniversitySt. LouisUSA

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