Physiology and Pathophysiology of Human Neutrophils
Circulating blood phagocytes, including neutrophils (polymorphonuclear leukocytes [PMN]) as well as monocytes, can recognize, ingest, kill, and, to a certain extent, digest microbes. These blood cells, therefore, are of crucial importance in host defense against invading microorganisms. Disorders in this line of defense are accompanied by serious, recurrent bacterial and fungal infections. In the last decade, a number of these often inherited disorders have been classified and their origin recognized.
KeywordsGlutathione Superoxide Hydrocortisone Adenosine Histamine
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- 1.S. J. Klebanoff and R. A. Clark, “The Neutrophil: Function and Clinical Disorders,” North-Holland Publishing Company, Amsterdam/New York/Oxford (1978).Google Scholar
- 6.J. I. Gallin, E. K. Gallin, H. L. Malech, E. B. Cramer, Structural and ionic events during leukocyte chemotaxis, in: “Leukocyte Chemotaxis: Methods, Physiology and Clinical Implications,” J. I. Gallin and P.G. Quie, eds., Raven Press, New York (1978).Google Scholar
- 13.I. Rivkin, J. Rosenblatt, E. L. Becker, The role of cyclic AMP in the chemotactic responsiveness and spontaneous motility of rabbit peritoneal neutrophils. The inhibition of neutrophil movement and the elevation of cyclic AMP levels by catecholamines, prostaglandins, theophylline, and cholera toxin, J Immunol 115: 1126 (1975).PubMedGoogle Scholar
- 15.N. D. Goldberg, M. K. Haddox, S. E. Nicol, D. B. Glass, C. H. Sanford, F. A. Kuehl, Jr., R. Estensen, Biologic regulation through opposing influences of cyclic GMP and cyclic AMP: the Yin-Yang hypothesis, in: “Advances in Cyclic Nucleotide Research,” G. I. Drummond, P. Greengard, and G. A. Robison, eds., Raven Press, New York (1975).Google Scholar
- 17.R. S. Weening, E. P. Schoorel, D. Roos, M. L. J. van Schaik, A. A. Voetman, A. A. M. Bot, A. M. Batenburg-Plenter, Ch. Willems, W. P. Zeijlemaker, A. Astaldi, Effect of ascorbate on abnormal neutrophil, platelet, and lymphocyte function in a patient with the Chediak-Higashi syndrome, Blood 57: 856 (1981).Google Scholar
- 30.P. Davies, A. C. Allison, R. I. Fox, M. Polyzonis, A. D. Haswell, The exocytosis of polymorphonuclear-leucocyte lysosomal enzymes induced by cytochalasin B, Biochem J 128: 78 (1972).Google Scholar
- 45.J. K. Spitznagel, M. R. Cooper, A. E. McCall, L. R. DeChatelet, I. R. H. Welsh, Selective deficiency of granules associated with lysozyme and lactoferrin in human polymorphs (PMN) with reduced microbicidal capacity, J Clin Invest 51: 93a (1972).Google Scholar
- 46.R. B. Johnston, Jr. and S. L. Newman, Chronic granulomatous disease. Pediatric Clinics of North-America, vol. 24 /2: 365, WB Saunders, Philadelphia (1977).Google Scholar