Advertisement

Lymphocyte Migration Studies in Man

  • John Wagstaff
Part of the NATO ASI Series book series (NSSA, volume 88)

Abstract

Over 200 years ago William Hewson (1) shrewdly observed that,

“Vast numbers of central particles (Lymphocytes) made by the thymus and lymphatic glands, are poured into the blood vessels through the thoracic duct and if we examine the blood attentively we can see them floating in it. Nature surely would not make so infinitely many particles to answer no purpose! What then becomes of these particles after they are mixed with the circulating blood are they immediately destroyed? No. They are we believe, carried with the blood to the spleen, not that the spleen has any elective attraction over them but that being equally and uniformly diffused through the general mass of blood, a due proportion is received by the spleen with its arterial blood, and that when arrived there, the spleen has the power of separating them from the other parts of the blood...”.

Keywords

Synovial Fluid Chronic Lymphocytic Leukemia Peripheral Blood Lymphocyte Human Lymphocyte Chronic Lymphocytic Leukemia Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    W. Hewson, in: The works of William Hewson“, Gulliver, FRS, p 275, London, 1846. Printed for the Sydenham Society.CrossRefGoogle Scholar
  2. 2.
    W. Fleming, “Studien uber regeneration der gewebe. I. Die Zellrermehrung in den Lymphadrusen und verwandten Organen, und ihr Einfluss auf Deren Bau,” Max Cohen und Sohn, Bonn 1885.Google Scholar
  3. 3.
    M. De Sousa, “Lymphocyte circulation: Experimental and clinical aspects,” John Wiley & Sons, Chichester, England 1981.Google Scholar
  4. 4.
    W. L. Ford, Lymphocyte migration and immune response, Pros Allergy 19: 1, 1981.Google Scholar
  5. 5.
    J. L. Gowans, The recirculation of lymphocytes from blood to lymph in the rat, J Physiol 146: 54, 1959.PubMedGoogle Scholar
  6. 6.
    J. Sprent, Recirculating lymphocytes. in: “The Lymphocyte: Structure and Function,” Marcel Dekker, New York, 1977.Google Scholar
  7. 7.
    A. E. Ellis and M. De Sousa, Phylogeny of the lymphoid system. I. A study of the fate of circulating lymphocytes in plaice, Eur J Immunol 4: 338, 1974.PubMedCrossRefGoogle Scholar
  8. 8.
    R. G. Bell and J. J. Lafferty, The flow and cellular characteristics of cervical lymph from anaesthetized ducks. Aust J Exp Biol Med Sci 50: 611, 1972.PubMedCrossRefGoogle Scholar
  9. 9.
    H. Frost, R. N. P. Cahill, Z. Trnka, The migration of recirculating autologous and allogenic lymphocytes through single lymph nodes, Eur J Immunol 5: 839, 1975CrossRefGoogle Scholar
  10. 19.
    P. M. Chisholm, H. J. Danpure, G. Healy, S. Osman, Cell damage resulting from the labeling of rat lymphocytes and Hela S3 cells with In-111-oxine, J Nucl Med 20: 1308, 1979.PubMedGoogle Scholar
  11. 20.
    T. Issekutz, W. Chin, J. B. Hay, Measurement of lymphocyte traffic using In-111, Clin Exp Immunol 39: 216, 1980.Google Scholar
  12. 21.
    S. M. Sparshott, H. Sharma, J. D. Kelly, W. I. Ford, Factors influencing the fate of In-111-labeled lymphocytes after transfer to syngenic rats, J Immunol methods 41: 303, 1981.PubMedCrossRefGoogle Scholar
  13. 22.
    H. Frost, P. Frost, C. Wilcos, Lymph node scanning in sheep with In-1P1-labeled lymphocytes Int J Nucl Med Biol 6: 60, 1979.PubMedCrossRefGoogle Scholar
  14. 23.
    J. P. Lavender, J. M. Goldman, R. N. Arnot, M. L. Thakur, Kinetics of In-111-labeled lymphocytes in normal subjects and patients with Hodgkin’s disease, Br Med J 2: 797, 1977.PubMedCrossRefGoogle Scholar
  15. 24.
    R. J. M. ten-Berrge, A. T. Natarajan, M. R. Hardeman, E. A. Van Royen, P. TH. A. Schellekens, Labeling with In-111 has detrimental effects on human lymphocytes: concise communication, J Nucl Med 24: 615, 1983.Google Scholar
  16. 25.
    J. Wagstaff, C. Gibson, N. Thatcher, W. L. Ford, H. Sharma, W. Benson, D. Crowther, A method for following human lymphocyte traffic using Indium oxine labeling, Clin Exp Immunol 43: 435, 1981.PubMedGoogle Scholar
  17. 10.
    J. G. Hall, An essay on lymphocyte circulation and the gut, Monogr Allergy 16: 100, 1979.Google Scholar
  18. 11.
    D. Guy-Grand, C. Griscelli, P. Vassalli, The mouse gut T lymphocyte, a novel type of T cell; nature, origin, and traffic in mice in normal and GVH conditions, J Exp Med 148: 1661, 1978.PubMedCrossRefGoogle Scholar
  19. 12.
    J. J. Woodruff and B. M. Gesner, The effect of neuraminidase on the fate of transfused lymphocytes, J Exp Med 129: 361, 1969.CrossRefGoogle Scholar
  20. 13.
    W. L. Ford, Lymphocyte migration and immune response, Prog Allergy 19: 1, 1975.PubMedGoogle Scholar
  21. 14.
    R. W. Gillette, G. O. McKenzie, and M. M. Swanson, Effect of concanavalin A on the homing of labeled T lymphocytes, J Immunol III: 1902, 1973.Google Scholar
  22. 15.
    A. A. Freitas and M. de Sousa, Controlled mechanisms of lymphocyte traffic. Modification of the traffic of Cr-52labeled mouse lymph node cells by treatment with plant lectins in the intact and splenectomized host, Eur J Immunol 5: 831, 1975.CrossRefGoogle Scholar
  23. 16.
    G. R. Blackledge, Flow cytometric investigations of DNA and the cell surface in normal and malignant cells, PHD Thesis, University of Manchester, Manchester, England, 1981.Google Scholar
  24. 17.
    A. S. G. Curtis, Clues concepts and possible answers from other systems in lymphocyte circulation, Auth de Sousa, John Wiley and Sons, Chichester, England, 1981.Google Scholar
  25. 18.
    R. F. Barth and O. Singla, Organ distribution of Tc-99m and Cr-51-labeled lymphocytes, J Nucl Med 16: 633, 1975.PubMedGoogle Scholar
  26. 26.
    J. Wagstff, C. Gibson, N. Thatcher, D. Crowther, A method for studying the dyanamics of primary migration of human lymphocytes using In-111-oxine cell labeling, in::In vivo Immunology,“ Nieuwenhuis, van den Broek and Hanna, eds., Plenum, p 153, 1982.Google Scholar
  27. 27.
    P. Hersey, The separation of Cr-51 labeling of human lymphocytes with in vivo studies of survival and migration, Blood 38: 360, 1971.PubMedGoogle Scholar
  28. 28.
    J. L. Scott, J. G. Davidson, J. V. Marino, R. MacMillian, Leukocyte labeling with Cr-51. III. The kinetics of normal lymphocytes, Blood 40: 276, 1972.PubMedGoogle Scholar
  29. 29.
    P. A. Strykmans, L. Debusscher, E. collard, Cell kinetics in CLL, Clin Haematol 6: 159, 1977.Google Scholar
  30. 30.
    M. B. Bazerbashi, J. Reeve, I. Chanarin, Studies in CLL. The kinetics of Cr-51-labeled lymphocytes, Scand J Haematol 20: 37, 1978.PubMedCrossRefGoogle Scholar
  31. 31.
    J. Manaster, J. Fribling, P. Strylsmans, Kinetics of lymphocytes in chronic lymphocytic leukaemia. I. Equilibrium between blood and a “readily accessible pool, ” Blood 41: 425, 1973.PubMedGoogle Scholar
  32. 32.
    J. Wagstaff, C. Gibson, N. Thatcher, D. Crowther, The migratory with CLL, Br J Haematol 49: 283, 1981.PubMedCrossRefGoogle Scholar
  33. 33.
    J. L. Scott, R. MacMillan, J. V. Manno, J. G. Davidson, Leukocyte labeling with Chromium-51. IV. The kinetics of CLL lymphocytes, Blood 41: 55, 1973.Google Scholar
  34. 34.
    G. H. Rannie and K. J. Donald, Estimation of the migration of thoracic duct lymphocytes to non-lymphoid tissues, Cell Tissue Kinet 10: 523, 1977.PubMedGoogle Scholar
  35. 35.
    L. Moretta, M. Ferrarini, M. C. Mingari, A. Moretta, S. R. Webb, Subpopulations of human T cells identified by receptors for immunoglobulins and mitogen responsiveness, J Immunol 117: 2171, 1976.PubMedGoogle Scholar
  36. 36.
    S. Romagni, E. Maggi, Biaggiotti, M. Guidizi, A. Anadori, M. Ricci, Altered proportion of Tu and T cell subpopulations in patients with Hodgkin’s disease, Scand J Immunol 7: 511, 1978.CrossRefGoogle Scholar
  37. 37.
    S. Gupta and C. T. C. Tan, Subpopulations of human T lymphocytes. XIV. Abnormality of T cell locomotion and of distribution of subpopulations of T and B lymphocytes in peripheral blood and spleens from children with untreated Hodgkin’s disease, Clin Immunol Immunopathol 15: 133, 1980.PubMedCrossRefGoogle Scholar
  38. 38.
    M. De Sousa, M. Yamg, E. Lopes-Corrales, C. Tan, J. A. Hansen, B. Dupont, R. A. Good Ecotaxis: The principle and its application to the study of Hodgkin’s disease, Clin Exp Immunol 27: 143, 1977.PubMedGoogle Scholar
  39. 39.
    M. M. Black, S. R. Opler, F. D. Speer, Survival in breast cancer cases in relation to the structure of the primary tumor and regional lymph nodes, Surg Gyn Obst 100: 543, 1955.PubMedGoogle Scholar
  40. 40.
    M. M. Zatz, A. White, A. L. Goldstein, Alterations in lymphocyte populations in tumorigenesis, J Immunol 3: 706, 1974.Google Scholar
  41. 50.
    R. Fleischmajer, V. Damiano, A. Nedwich, Alteration of ‘subcutaneous tissue in systemic scleroderma, Arch Dermatol 105: 59, 1972.PubMedCrossRefGoogle Scholar
  42. 51.
    A. J. Barnett, “Scleroderma,” Charles C. Thomas, Springfield, Il., p 14, 1974.Google Scholar
  43. 52.
    M. A. Scheinberg, E. S. Cathcut, B and T cell lymphopenia in systemic lupus erythematosus, Cell Immunol 12: 309, 1974.PubMedCrossRefGoogle Scholar
  44. 53.
    G. P. Rodnan and T. A. Medoger, Musculoskeletal involvement in progressive systemic sclerosis (scleroderma), Bull Rheum dis 17: 419, 1966.Google Scholar
  45. 54.
    W. J. Williams, A study of Crohn’s syndrome using tissue extracts and the kveim and mantoux tests, Gut 6: 503, 1965.PubMedCrossRefGoogle Scholar
  46. 55.
    J. V. Jones, J. Housley, P. M. Ashurst, C. F. Hawkins, Development of delayed hypersensitivity to dinitrochlorobenzene in patients with Crohn’s disease, Gut 10: 52, 1969.PubMedCrossRefGoogle Scholar
  47. 41.
    J. Wagstaff, C. Gibson, N. Thatcher, W. L. Ford, H. Sharma, D. Crowther (1981) Human lymphocyte traffic assessed by In-111oxine labeling: clinical observations, Clin Exp Immunology 43: 443, 1981.Google Scholar
  48. 42.
    S. S. Froland, J. B. Natvig, G. Husby, Immunological characterization of lymphocytes in synovial fluid from patients with rheumatoid arthritis, Scand J Immunol 2: 67, 1973.PubMedCrossRefGoogle Scholar
  49. 43.
    R. J. Winchester, J. B. Winfield, F. Siegel, P. Wernet, Z. Bentwich, H. G. Kinkel, Analysis of lymphocytes from patients with rheumatoid arthritis and systemic lupis erythematous, J Clin Invest 54: 1082, 1974.PubMedCrossRefGoogle Scholar
  50. 44.
    P. J. Sheldon, M. Pappamichail, E. J. Holborow, Studies on synovial fluid lymphocytes in rheumatoid arthritis, Ann Rheum Dis 33: 509, 1974.PubMedCrossRefGoogle Scholar
  51. 45.
    B. Vernon-Roberts, H. L. F. Currey, J. Penin, T and B cells in the blood and synovial fluid of rheumatoid arthritis patients, Ann Rheum Dis 33: 430, 1974.PubMedCrossRefGoogle Scholar
  52. 46.
    A. I. Brenner, M. A. Scheinberg, E. S. Cathcart, Surface characteristics of synovial fluid and peripheral blood lymphocytes in inflammatory arthritis, Arthritis Rheum 18: 297, 1975.PubMedCrossRefGoogle Scholar
  53. 47.
    L. B. A. Van de Putte, C. J. L. M. Meijer, G. J. M. Lafebar, R. Kleinjan, A. Cats, Lymphocytes in rheumatoid arthritis and non-rheumatoid synovial fluids, Ann Rheum Dis 35: 451, 1976.Google Scholar
  54. 48.
    U. Galili, L. Rosentahl, N. Galilia, E. Klein, Activated T cells in synovial fluid of arthritic patients: Characterization and comparison with in vitro activated human and murine T cells in cooperation with monocytes in cytotoxicity, J Immunol 122: 878, 1979.PubMedGoogle Scholar
  55. 49.
    D. A. Goodwin, Indium-labeled leukocytes in inflammatory diseases, Symposium on cell and protein labeling with gammaemitting radionucliedes for in vivo study, British Institute Radiology, 1980.Google Scholar
  56. 56.
    K. Parent, J. Barrett, I. D. Wilson, Investigation of the pathogenic mechanisms in regional enteritis with in vitro lymphocyte cultures, Gastroenterology 61: 431, 1971.PubMedGoogle Scholar
  57. 57.
    P. J. Guillou, T. G. Brennan, G. R. Giles, Lymphocyte transformation in the mesenteric lymphnodes of patients with Crohn’s disease, Gut 14: 20, 1973.PubMedCrossRefGoogle Scholar
  58. 58.
    D. B. Sachar, R. N. Taub, S. M. Brown, D. H. Present, B. Kovelitz, H. D. Janowitz, Impaired lymphocyte responsiveness in inflammatory bowel disease, Gastroenterology 64: 203, 1973.PubMedGoogle Scholar
  59. 59.
    R. G. Strickland, G. Husby, W. C. Black, R. C. Williams, Peripheral blood and intestinal lymphocyte populations in Crohn’s disease, Gut 16: 847, 1975.PubMedCrossRefGoogle Scholar
  60. 60.
    A. P. Douglas, A. P. Weetman, J. W. Haggith, The distribution and enteric loss of Cr-51-labeled lymphocytes in normal subjects and in patients with coeliac disease and other disorders of the small intestine, Digestion 14: 29, 1976.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • John Wagstaff
    • 1
  1. 1.Cancer Research Campaign Department Medical OncologyChristie Hospital and Holt Radium InstituteManchesterEngland

Personalised recommendations