Hypnosis and Plasmatic Beta-Endorphins

  • G. Guerra
  • G. Guantieri
  • F. Tagliaro


The importance of B-endorphins and other polypetides has been demonstrated recently in the central modulation of pain and in analgesia. Diagnostic and clinical implications have been prospected in the pain field, and in relation with B-endorphins affinity with endogenous opiate receptor, in opiates addiction.

Owing to the difficulty of B-endorphin determination in biological fluids, the studies have supplied interesting but contradictory results. We have less information about the behavior of these neuropeptides during hypnosis under neutral, analgesic and painful suggestions and this is the field of our research. The authors are studying normal and heroin addicted subjects. Plasmatic B-endorphin determination is performed by a radio-immunologic method after a chromatographic step (gel filtration or HPLC). Preliminary data would suggest interesting modifications of B-endorphins in peripheral blood during strong suggestions of pain in the hypnotic state.


Opiate Receptor Periaqueductal Gray Matter Endogenous Opiate Animal Hypnosis Hypnotic State 
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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • G. Guerra
    • 1
  • G. Guantieri
    • 2
  • F. Tagliaro
    • 3
  1. 1.Hospital Service CommandRMNEVeronaItaly
  2. 2.Center for Studies on Clinical Hypnosis and PsychotherapyVeronaItaly
  3. 3.Institute for Medical SemeioticsUniversity of PadovaVeronaItaly

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