Distribution of Slow Myosin in Dystrophic Chicken Muscle
Avian muscular dystrophy is a disorder that preferentially affects the development of fast twitch muscles (215,218). Previous research using anatomical, histochemical, and biochemical methods have demonstrated clear dystrophic abnormalities in the posterior latisslmus dorsi (PLD) while the anterior latissimus dorsi (ALD), a slow tonic muscle, is unaffected by the disease (216,219). Most of this research has been performed on normal and dystrophic chickens of different genetic backgrounds. While avian muscular dystrophy is caused by a single autosomal recessive gene, the dystrophic gene causes relatively rapid fiber atrophy when placed on a New Hampshire background (217,220). These effects are most likely due to differences in the rate of muscle growth in the two breeds. Since inbred lines of normal and dystrophic chickens now exist that contain greater than 90% of their genes in common, these strains (normal line 03 and dystrophic line 433) were used for the current study to ensure that the differences observed between normal and dystrophic muscles were due to the disease.
KeywordsMyosin Heavy Chain Medial Gastrocnemius Dystrophic Muscle Intrafusal Fiber Slow Myosin
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