Multigene Families, Differential Transcription and Differential Splicing: Different Origin of Contractile Isoproteins in Muscle

  • Emmanuel E. Strehler
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 182)


I would like to summarize some of the results obtained in Bernardo Nadal-Ginard’s lab in the last two years concerning the number, structure and regulation of the genes for the isoforms of rat muscle protein, I will concentrate on the gene(s) for three of these proteins: myosin heavy chain (MHC), myosin light chain 1/3 (LC1/3) and Troponin T (TNT). The work to be presented has been carried out in collaboration with the following investigators in our lab: MHC: Vijak Mahdavi, Danuta Bois, Muthu Periasamy, Robert Wydro and Russell Medford; LC1/3: Muthu Periasamy and Leonard Garfinkel; TNT: Hanh Nguyen, Russell Medford and Antonia Destree.


Myosin Heavy Chain Myosin Light Chain Thick Filament Differential Splice Adult Skeletal Muscle 
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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Emmanuel E. Strehler
    • 1
  1. 1.Department of CardiologyChildren’s HospitalBostonUSA

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