Parvalbumin Reduction in Relation to Possible Perturbations of CA2+ -Homeostasis in Muscular Dystrophy
It has been suggested that muscle wasting in muscular dystrophy is causally related to a perturbation of Ca2+ -homeostasis in the muscle fiber (8,525–530) due to an increased permeability of the sarcolemmal membrane. An elevated sarcoplasmic Ca2+ concentration would result from an increased Ca2+ -influx and would thus lead to an activation of Ca2+ -dependent proteases. Ca2+ has also been shown to play an important role in the regulation of glucose-1,6-biphosphate (531,532) a powerful effector of several enzymes in glucose metabolism (533). This modulator has been shown to be significantly reduced in muscles of dystrophic mice (534,535).
KeywordsMuscular Dystrophy Fiber Type Hindlimb Muscle Dystrophic Muscle Powerful Effector
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