Myotrophic Factor(s) in Normal and Dystrophic Chicken Skeletal Muscle
In our earlier work on satellite cell cultures (358) we noticed that slow muscle like the anterior latissimus dorsi (ALD) yielded a higher number of satellite cells than did the fast pectoralis major muscle (PM). We have now found that the ALD contains a high level of a muscle growth factor and we have identified this factor as transferrin (Tf) 359). In addition, Tf was found to be relatively low in normal PM muscle but elevated in PM muscle obtained from chickens with inherited muscular dystrophy (360). Finally, we have recently been able to show that the Tf fractions from ALD and dystrophic PM muscle contain a growth-promoting factor other than Tf which we have yet to identify. The Tf studies are published (359, 360) and we will simply summarize them here with an attempt to relate the findings to normal and dystrophic muscle growth.
KeywordsSatellite Cell Pectoralis Major Muscle Slow Muscle Embryo Extract Muscle Stimulate Protein Synthesis
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