Cerebral Cortical Oxygenation and Perfusion during Hetastarch Hemodilution
Clinically, hemodilution may be induced under various circumstances such as intraoperatively during cariopulmonary bypass (1) or therapeutically (2,3). However, aside from its clear-cut efficacy in polycythemic patients (3) and in other pathologic circumstances (2), there is some doubt as to whether tissue oxygenation is improved by hemodilution to subnormal hematocrits (4). With regard to oxygen delivery to the myocardium, Lundsgaard-Hansen (4) concluded that hemodilution should not exceed the lower normal range of hemoglobin or hematocrit (Hct), namely, 12.0 to 12.5% and 35 to 36%, respectively. Our aim in this study was to determine the effects of progressive, normovolemic hemodilution with hydroxy ethyl starch over Hct ranging from 40 to 5% on cerebral cortical oxygenation and perfusion.
KeywordsMean Arterial Pressure Hydroxy Ethyl Starch Group Anesthesia Local Cerebral Blood Flow Threshold Phenomenon
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- 2.Pichlmayr I: Hamodilution, Grundlagen und Praxis. Anasth Prax. 12:41–48, 1976.Google Scholar
- 6.Nemoto EM, Frinak S, Taylor F: Postischemic brain oxygenation with barbiturate therapy in rats. Stroke 7:339–345, 1979.Google Scholar
- 10.Lubbers DW: Die Bedeutung des lokalen Gewebesauerstoffdruckes und des PO2-Histogrammes fur die Beurteilung der Sauerstoffversorgung eines Organes. Prakt. Anasth 12: 184–196, 1977.Google Scholar