Cerebral Cortical Oxygenation and Perfusion during Hetastarch Hemodilution

  • Tadashi Shinozuka
  • Edwin M. Nemoto
  • Achiel L. Bleyaert
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 180)


Clinically, hemodilution may be induced under various circumstances such as intraoperatively during cariopulmonary bypass (1) or therapeutically (2,3). However, aside from its clear-cut efficacy in polycythemic patients (3) and in other pathologic circumstances (2), there is some doubt as to whether tissue oxygenation is improved by hemodilution to subnormal hematocrits (4). With regard to oxygen delivery to the myocardium, Lundsgaard-Hansen (4) concluded that hemodilution should not exceed the lower normal range of hemoglobin or hematocrit (Hct), namely, 12.0 to 12.5% and 35 to 36%, respectively. Our aim in this study was to determine the effects of progressive, normovolemic hemodilution with hydroxy ethyl starch over Hct ranging from 40 to 5% on cerebral cortical oxygenation and perfusion.


Mean Arterial Pressure Hydroxy Ethyl Starch Group Anesthesia Local Cerebral Blood Flow Threshold Phenomenon 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Tadashi Shinozuka
    • 1
  • Edwin M. Nemoto
    • 1
  • Achiel L. Bleyaert
    • 1
  1. 1.The Anesthesia and CCM Research Laboratories, Department of Anesthesiology and Critical Care MedicineUniv. of PittsburghPittsburghUSA

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