Direct Measurement of Reoxygenation in Malignant Mammary Tumors after a Single Large Dose of Irradiation

  • P. Vaupel
  • S. Frinak
  • M. O’Hara
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 180)


Due to functional and morphological abnormalities of the terminal vascular bed in malignant tumors, a severe restriction of convective transport occurs even in very early growth stages. This leads to nutritional deprivation of the cancer cells and to unfavourable cellular microenvironments as well. During advanced tumor growth stages, the nutritional deprivation and the milieu conditions get worse because pronounced deterioration of diffusive transport is superimposed on the insufficient blood supply. This transport limitation is mainly caused by increases of intercapillary distances and by decreases of vascular surface areas per unit tissue volume. Moreover, these peculiarities of the tumor microcirculation are randomly spread over the whole tumor mass. Besides these spatial inhomogeneities, temporal heterogeneities of the supply conditions are also evident in tumors (for a review see Vaupel et al., 1981)


Oxygen Removal Tumor Blood Flow Tissue Oxygen Tension Bare Platinum Single Large Dose 
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  1. Badib, A.O., and Webster, J.H., 1969, Changes in tumor oxygen tension during radiation therapy, Acta Radiol., 8: 247.CrossRefGoogle Scholar
  2. Bergsjø, P., and Evans, J.C., 1968, Oxygen tension of cervical carcinoma during the early phase of external irradiation. I. Measurements with a Clark micro electrode, Scand. J. clin. Lab. Invest., 22 (Suppl. 106): 159.Google Scholar
  3. Bergsjø, P., and Evans, J.C., 1971, Oxygen tension of cervical carcinoma during the early phase of external irradiation. II. Measurements with bare platinum micro electrodes. Scand. J. clin. Lab. Invest., 27: 71.PubMedCrossRefGoogle Scholar
  4. Cater, D.B., and Silver, I.A., 1960, Quantitative measurements of oxygen tension in normal tissues and in the tumours of patients before and after radiotherapy, Acta Radiol., 53: 233.PubMedCrossRefGoogle Scholar
  5. Clement, J.J., Song, C.W., and Sand, T.T., 1978, Tumor cell respiration following irradiation. Radiology, 126: 507.PubMedGoogle Scholar
  6. Constable, T.B., 1976, The effect of irradiation on the oxygen removal rate of the SSBIa rat fibrosarcoma, Europ. J. Cancer, 12: 963.Google Scholar
  7. Constable, T.B., and Naylor, P.F.D., 1978, The effect of irradiation on the rate of oxygen removal in the Lewis lung carcinoma, Europ. J. Cancer, 14: 1309.Google Scholar
  8. Durand, R.E., and Sutherland, R.M., 1976, Repair and re-oxygenation following irradiation of an in vitro tumor model. Int. J. Radiat. Oncol. Biol. Phys., 1: 1119.PubMedCrossRefGoogle Scholar
  9. Emami, B., Ten Haken, R.K., Nussbaum, G.H., and Hughes, W.L., 1981, Effects of single- dose irradiation on tumor blood flow studied by 15–0 decay after photon activation in situ, Radiology, 141: 207.PubMedGoogle Scholar
  10. Evans, N.T.S., and Naylor, P.F.D., 1963, The effect of oxygen breathing and radiotherapy upon the tissue oxygen tension of some human tumours. Brit. J. Radiol., 36: 418.CrossRefGoogle Scholar
  11. Hall E.J., 1978, Radiobiology for the radiologist, Ed. 2, Harper and Row Publishers, Hagerstown, Md.Google Scholar
  12. Howes, A.E., 1969, An estimation of changes in the proportions and absolute numbers of hypoxic cells after irradiation of transplanted C3H mouse mammary tumours Brit. J. Radiol., 42: 441.PubMedCrossRefGoogle Scholar
  13. Kallman, R.F., 1972, The phenomenon of reoxygenation and its implications for fractionated radiotherapy. Radiology, 105: 135.PubMedGoogle Scholar
  14. Kallman, R.F., DeNardo, G.L., and Stasch, M.J., 1972, Blood flow in irradiated mouse sarcoma as determined by the clearance of xenon-133. Cancer Res., 32: 483.PubMedGoogle Scholar
  15. Kollmorgen, G.M., and Bedford, J.S., 1973, Cellular radiation biology, in: Medical Radiation Biology, G.V. Dalrymple, M.E. Gaulden, G.J. Kollmorgen, and H.H. Vogel, eds., W.B. Saunders Co., Philadelphia.Google Scholar
  16. Mattsson, J., and Peterson, H.I., 1979, Irradiation and tumor blood flow, in: Tumor Blood Flow, H.I. Peterson, ed., CRC Press, Boca Raton, Fla.Google Scholar
  17. Mueller-Klieser, W., Vaupel, P., Manz, R., and Schmidseder, R., 1981, Intracapillary oxyhemoglobin saturation of malignant tumors in humans, Int. J. Radiat. Oncol. Biol. Phys., 7: 1397.PubMedCrossRefGoogle Scholar
  18. Pappova, N., Siracka, E., Vacek, A., and Durkovsky, J., 1982, Oxygen tension and prediction of the radiation response. Polarographic study in human breast cancer, Neoplasma, 29: 669.PubMedGoogle Scholar
  19. Peterson, H.I., Appelgren, L., Kjartansson, and Selander, D., 1976, Vascular and extravascular spaces in a transplantable rat tumour after local X- ray irradiation, Z. Krebsforsch., 87: 17.CrossRefGoogle Scholar
  20. van Putten, L.M., 1977, Reoxygenation of hypoxic tumour cells, Strahierttherapic, 153: 380.Google Scholar
  21. Suit, H.D., Howes, A.E., and Hunter, N., 1977, Dependence of response of a C3H mammary carcinoma to fractionated irradiation on fractionation number and intertreatment interval, Radiat. Res., 72: 440.PubMedCrossRefGoogle Scholar
  22. Suit, H.D., Sedlacek, R., Fagundes, L., Goitein, M., and Rothman, K.J., 1978, Time distributions of recurrences of immunogenic and nonimmunogenic tumors following local irradiation, Radiat. Res., 73: 251.PubMedCrossRefGoogle Scholar
  23. Trott, K.R., 1982, Experimental results and clinical implications of the four R’s in fractionated radiotherapy, Radiat. Environ. Biophys., 20: 159.PubMedCrossRefGoogle Scholar
  24. Vaupel, P., 1977, Hypoxia in neoplastic tissue, Microvasc. Res., 13: 399.PubMedCrossRefGoogle Scholar
  25. Vaupel, P., 1982, Pathophysiologie der Durchblutung maligner Tumoren, in: Funktionsanalyse biologischer Systeme, J. Grote, E. Witzleb, eds., Steiner Verlag, Wiesbaden.Google Scholar
  26. Vaupel, P., Frinak, S., and Bicher, H.I., 1981, Heterogeneous oxygen partial pressure and pH distribution in C3H mouse mammary adenocarcinoma. Cancer Res., 41: 2008.PubMedGoogle Scholar
  27. Vaupel, P., Müller-Klieser, W., Manz, R., Wendling, P., Strube, H.D., and Schmidseder, R., 1983, Heterogeneous oxygenation of malignant tumors in humans, Verh. Dtsch. Krebs- Ges., 4: 153.Google Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • P. Vaupel
    • 1
  • S. Frinak
    • 2
  • M. O’Hara
    • 2
  1. 1.Dept. Applied PhysiologyUniversity of MainzMainzW.- Germany
  2. 2.Div. Radiation BiologyHenry Ford HospitalDetroitUSA

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