Effect of H2 Receptor- and Muscarine Receptor Antagonists and Prostaglandin E1 Analog on the Gastric Mucosal Hemodynamics and Oxygen Sufficiency in Rats

  • Nobuhiro Sato
  • Li Hu Quan
  • Sunao Kawano
  • Takenobu Kamada
  • Hiroshi Abe
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 180)


Recently-introduced anti-ulcer agents such as H2 receptor antagonist and selective muscarinic receptor antagonist have yielded a good therapeutic result for intractable peptic ulcer. These drugs have a powerful anti-secretory effect. Possible additional effects of these drugs, however, have also been discussed (1–3). Prostaglandins (PGs) and their analogs have been reported to show potent gastric anti-secretory action (4) and inhibit the experimental ulceration independently of any anti-secretory action (5). It is suggested that PGs have a “cytoprotective effect” on the gastric mucosa (6).


Gastric Mucosa Hemorrhagic Shock Mucosal Blood Flow Gastric Mucosal Blood Flow Reflectance Spectrophotometry 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Nobuhiro Sato
    • 1
  • Li Hu Quan
    • 1
  • Sunao Kawano
    • 1
  • Takenobu Kamada
    • 1
  • Hiroshi Abe
    • 1
  1. 1.Department of MedicineOsaka University Medical SchoolOsakaJapan

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