Effect of H2 Receptor- and Muscarine Receptor Antagonists and Prostaglandin E1 Analog on the Gastric Mucosal Hemodynamics and Oxygen Sufficiency in Rats
Recently-introduced anti-ulcer agents such as H2 receptor antagonist and selective muscarinic receptor antagonist have yielded a good therapeutic result for intractable peptic ulcer. These drugs have a powerful anti-secretory effect. Possible additional effects of these drugs, however, have also been discussed (1–3). Prostaglandins (PGs) and their analogs have been reported to show potent gastric anti-secretory action (4) and inhibit the experimental ulceration independently of any anti-secretory action (5). It is suggested that PGs have a “cytoprotective effect” on the gastric mucosa (6).
KeywordsGastric Mucosa Hemorrhagic Shock Mucosal Blood Flow Gastric Mucosal Blood Flow Reflectance Spectrophotometry
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