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Dual Role of Diffusion in Tissue Gas Exchange: Blood-Tissue Equilibration and Diffusion Shunt

  • Johannes Piiper
  • Michael Meyer
  • Peter Scheid
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 180)

Abstract

In a previous study the washout kinetics of two inert gases of different diffusivity, methane (CH4) and sulfur hexafluoride (SF6), was found to be incompatible with the assumption of exclusive perfusion limitation (Piiper and Meyer, in press). Also models with additional tissue-blood diffusion limitation could not explain the experimental findings. Only a model incorporating veno-arterial back diffusion appeared to provide a satisfactory agreement between model predictions and experimental data.

Keywords

Diffusion Limitation Washout Rate Sulfur Hexafluoride Local Blood Flow Washout Time 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Adaro, F., Scheid, P., Teichmann, J. and Piiper, J., 1973, A rebreathing method for estimating pulmonary DO2: theory and measurements in dog lungs., Respir. Physiol. 18: 43–63.PubMedCrossRefGoogle Scholar
  2. Kety, S.S., 1951, Theory and application of the exchange of inert gas at the lungs and tissues, Pharmacol. Rev. 3: 1–41.PubMedGoogle Scholar
  3. Lassen, N.A., Lindbjerg, I. and Munck, O., 1964, Measurement of blood flow through skeletal muscle by intramuscular injection of xenon133, Lancet 1: 686–689.PubMedCrossRefGoogle Scholar
  4. Ohta, Y., Song, S.H., Groom, A.C. and Farhi, L.E., 1978, Is inert gas washout from tissues limited by diffusion? J. Appl. Physiol. 45: 903–907.PubMedGoogle Scholar
  5. Ohta, Y. and Farhi, L.E., 1979, Cerebral gas exchange: perfusion and diffusion limitation, J. Appl. Physiol. 46: 1164–1168.PubMedGoogle Scholar
  6. Piiper, J. and Scheid, P., 1981, Model for capillary alveolar equilibration with special reference to O2 uptake in hypoxia, Respir. Physiol. 46: 193–208.PubMedCrossRefGoogle Scholar
  7. Piiper, J. and Meyer, M., in press, Diffusion-perfusion relationships in skeletal muscle: models and experimental evidence from inert gas washout, Proceedings, ISOTT Meeting, Dortmund, 1982.Google Scholar
  8. Stosseck, K., Lübbers, D.W. and Cotten, N., 1974, Determination of local blood flow (microflow) by electrochemically generated hydrogen. Pflügers Arch. 348: 225–238.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Johannes Piiper
    • 1
  • Michael Meyer
    • 1
  • Peter Scheid
    • 1
  1. 1.Abteilung PhysiologieMax-Planck-Institut für experimentelle MedizinGöttingenGermany

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