Advertisement

Enhancement of P50 by Inositol Hexa Phosphate Entrapped in Resealed Erythrocytes in Piglets

  • B. Teisseire
  • C. Ropars
  • C. Nicolau
  • M. O. Vallez
  • M. Chassaigne
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 180)

Abstract

Lowering hemoglobin affinity for oxygen improves O2 release capacity but two physiological consequences of an increase in P50 are expected: 1/ an increase in oxygen tension in peripheral capillary blood, 2/ a decrease in blood perfusion in order to minimize the amplitude of change in capillary oxygen tension (GUYTON, 1976). To maintain oxygen uptake, tissular perfusion should be regulated by a vascular constriction and the increased capillary-tissue O2 diffusion would be compensated for by a lowered O2 transport.

Keywords

Release Capacity Exchange Transfusion Oxygen Affinity Rightward Shift Oxygen Hemoglobin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Benesch, R.E., Edalji R., Benesch R. 1977, Reciprocal interaction of hemoglobin with oxygen and protons. The influence of allosteric polyanions, Biochemistry 16: 2594–2597PubMedCrossRefGoogle Scholar
  2. Gersonde, K., Nicolau C. 1979, Improvement of the red blood cells O2 release capacity by lipid vesicle-mediated incorporation in inositol hexaphosphate, Blut, 39: 1–7PubMedCrossRefGoogle Scholar
  3. Guyton, A.C. 1976, in “Textbook of medical physiology”, W.B. Saunders Co., PhiladelphiaGoogle Scholar
  4. Krall, M.A., Bristol J.D., Welch J.E. and Metalfe J. 1978, Physiological effects of lowered blood oxygen affinity in dogs, Respir. Physiol. 33: 263–270PubMedCrossRefGoogle Scholar
  5. Soulard, C.D., Teisseire B.P., Teisseire L.J., Hérigault R.A. 1983, Consequences of an acute increase in P50 anesthetized guinea pigs, Respir. Physiol. 51: 21–30PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • B. Teisseire
    • 1
  • C. Ropars
    • 2
  • C. Nicolau
    • 3
  • M. O. Vallez
    • 1
  • M. Chassaigne
    • 3
  1. 1.U 138 INSERM Hôpital Henri MondorCréteilFrance
  2. 2.ERA 697 CNRS CTSToursFrance
  3. 3.Lab. Biophys. Mol. CNRSOrléansFrance

Personalised recommendations