Enhancement of P50 by Inositol Hexa Phosphate Entrapped in Resealed Erythrocytes in Piglets
Lowering hemoglobin affinity for oxygen improves O2 release capacity but two physiological consequences of an increase in P50 are expected: 1/ an increase in oxygen tension in peripheral capillary blood, 2/ a decrease in blood perfusion in order to minimize the amplitude of change in capillary oxygen tension (GUYTON, 1976). To maintain oxygen uptake, tissular perfusion should be regulated by a vascular constriction and the increased capillary-tissue O2 diffusion would be compensated for by a lowered O2 transport.
KeywordsRelease Capacity Exchange Transfusion Oxygen Affinity Rightward Shift Oxygen Hemoglobin
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- Guyton, A.C. 1976, in “Textbook of medical physiology”, W.B. Saunders Co., PhiladelphiaGoogle Scholar