Balance between O2 Availability and V̇O2 in Rest-Work Transition as Measured by Myoglobin Saturation in Subcellular Volumes

  • Carl R. Honig
  • Thomas E. J. Gayeski
  • Richard J. Connett
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 180)


The rate of O2 consumption (V̇O2) may increase 100-fold between rest and steady work in red skeletal muscles (1,2). Does hyperemia supply O2 at a rate which keeps pace with this massive increase in O2 demand, or is an O2 debt incurred? Does exercise hyperemia depend on O2 lack (3), a redox signal (4), or cytosolic energy charge (5)? To answer these questions we related the time course of exercise hyperemia to myoglobin (Mb) saturation in subcellular volumes (6,7). ATP, creatine phosphate (PCr), lactate (LA), and pyruvate (Pyr) concentrations were co-variates.


Flow Pulse Gracilis Muscle Vascular Smooth Muscle Contraction Copper Heat Sink Exercise Hyperemia 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Carl R. Honig
    • 1
  • Thomas E. J. Gayeski
    • 1
  • Richard J. Connett
    • 1
  1. 1.School of Medicine and DentistryThe University of RochesterRochesterUSA

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