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Measurements of Local PO2 in the Resting Skeletal Muscles of Rats with Portocaval Anastomosis (PCA) under Normoxic Conditions

  • R. Heinrich
  • W. Grauer
  • H. Schomerus
  • M. Günderoth
  • J. Hoeper
  • M. Kessler
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 180)

Abstract

Various hemodynamic changes have been described in patients with liver cirrhosis. It has been shown that alterations of pulmonary microcirculation, such as arteriovenous shunting leads to impairment of pulmonary gas transfer, which correlates with the degree of encephalopathy (Schomerus et al. 1975). The well known hyperdynamic cardiovascular state of patients with liver cirrhosis is characterized by an increased cardiac output, decreased peripheral vascular tone, increased mixed venous oxygen content and elevated mean systolic ejection rate (Gordon and Del Guercio 1972, Siegel et al. 1974). This hyperdynamic cardiovascular state has also been demonstrated in rats with portocaval end-to-side anastomosis (PCA), a well defined experimental model (Herz et al. 1972, Liehr et al. 1976). In rats with PCA little is known about the effects of changes in systemic circulation on tissue oxygenation of the muscles.

Keywords

Liver Cirrhosis Portocaval Shunt Portal Systemic Shunting Considerable Interindividual Variation Peripheral Vascular Tone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • R. Heinrich
    • 1
  • W. Grauer
    • 1
  • H. Schomerus
    • 1
  • M. Günderoth
    • 1
  • J. Hoeper
    • 2
  • M. Kessler
    • 2
  1. 1.Medizinische UniversitätsklinikTübingenFed. Rep. Germany
  2. 2.Institut für PhysiologieUniversität ErlangenFed. Rep. Germany

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