Advertisement

The Hypoxic Response to Hypovolemia

  • Hermann Metzger
  • Sabine Heuber-Metzger
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 180)

Abstract

The induction of hypovolemia within an organism triggers off many, closely associated processes whereby individual details of their spatial and temporal interactions are not yet fully understood. The most important primary responses to hypovolemia are:
  • reduction in the transport of O2 and CO2 molecules

  • decrease in velocity of capillary flow as a consequence of the resulting hypotension

  • change in capillary perfusion pattern of the various organs.

Keywords

Hypoxic Response Liver Surface Traumatic Shock Additional Trauma Small Blood Volume 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Eklöf, B., Macmillan, V., and Siesjö, B. L., 1972, Cerebral energy state and cerebral venous PO2 in experimental hypotension caused by bleeding, Acta Physiol. Scand. 86:515–527.PubMedCrossRefGoogle Scholar
  2. Fitts, C. T., Bicher, H. I., and Yarbrough III, D. R., 1973, Blood and tissue oxygenation during hemorrhagic shock as determined with ultra micro oxygen electrodes, Adv. Exp. Med. Biol. 37A:477–489.PubMedGoogle Scholar
  3. Kovách, A. G. B., 1973, Tissue blood flow and metabolism in control and phenoxybenzamine-pretreated animals in experimental shock, in: “Traumatic Shock”, G. Y. Szánta, W. Honig, O. Székely, ed., Akadémiai Kiadó, Budapest, pp. 163–185.Google Scholar
  4. Metzger, H., Erdmann, W., and Thews, G., 1971, Effect of short periods of hypoxia, hyperoxia and hypercapnia on brain O2 supply, J. Appl. Physiol. 31:751–759.PubMedGoogle Scholar
  5. Metzger, H., and Heuber, S., 1977, Local oxygen tension and spike activity of the cerebral grey matter of the rat and its response to short intervals of O2 deficiency or CO2 excess, Pflügers Arch. 370:201–209.PubMedCrossRefGoogle Scholar
  6. Metzger, H., Heuber-Metzger, S., Steinacker, A., and Strüber, J., 1980, Staining PO2 measurement sites in the rat brain cortex and quantitative morphometry of the surrounding capillaries, Pflügers Arch.388: 21–27.PubMedCrossRefGoogle Scholar
  7. Silver, L. A., 1978, Extracellular oxygen gradients in shock, in: “Frontiers of Biological Energetics”, P. I. Dutten, J. S. Leigh, A. Scarpa, ed., Academic Press, New York, pp. 1435–1443.Google Scholar
  8. Scherf, M., Oestern, H. J., and Metzger, H., in preparation, Studies of hemorrhagic and traumatic shock influence on liver oxygen tension. Effects of a single large dose of dexamethasone, submitted to Adv. Exp. Med. Biol. Google Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Hermann Metzger
    • 1
  • Sabine Heuber-Metzger
    • 1
  1. 1.Dept. of PhysiologyMedizinische Hochschule HannoverHannover 61Germany

Personalised recommendations