O2 Transport and Uptake in Dogs during CO Hypoxia with and without β-Block

  • Cheryl E. King
  • Stephen M. Cain
  • Christopher K. Chapler
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 180)


At levels of carboxyhemoglobin greater than 40% (CO hypoxia), cardiac output increases in anesthetized dogs (Einzig et al., 1980; Sylvester et al., 1979). At the same time, both sympathetic activity (Fitzgerald et al., 1976) and circulating levels of catecholamines are increased (Sylvester et al., 1979). In addition to these facts, Scharf et al. (1975) reported that left ventricular contractile performance, as measured by dp/dt, increase when isolated dog hearts were perfused with blood from donor dogs that had inhaled carbon monoxide. The increased ventricular dp/dt was abolished following β-adrenergic blockade; These findings suggest that β-adrenergic receptor activity is an important component in the cardiac response to CO hypoxia. With respect to the peripheral circulation, Cain and Chapler (1979) showed that β-adrenergic vasodilation contributed to the rise in hindlimb skeletal muscle blood flow which occurred in both anemic and hypoxic hypxia. To identify the role of β-adrenergic receptors during CO hypoxia, we have measured some of the cardiovascular and metabolic responses of the whole body and hindlimb skeletal muscle with and without propranolol to block β-adrenergic receptors.


Untreated Group Block Group Hypoxic Hypoxia Skeletal Muscle Blood Flow Cardiac Output Increase 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Cheryl E. King
    • 1
  • Stephen M. Cain
    • 1
  • Christopher K. Chapler
    • 2
  1. 1.Department of Physiology and BiophysicsUniversity of Alabama in BirminghamBirminghamUSA
  2. 2.Department of PhysiologyQueen’s UniversityKingstonCanada

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