Normal Values of Oxygen Concentration in Human Blood

  • Friedrich Mertzlufft
  • Rolf Zander
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 180)


Under physiological conditions, the oxygen supply as the product of O2-concentration (mlO2/dl; %(v/v)) and perfusion is influenced by many factors (cf. Fig. 1): perfusion on one hand, oxygen partial pressure (pO2; mmHg), haemoglobin (Hb) concentration (g/dl) and O2 binding power of Hb on the other hand. Under pathological conditions, oxygen supply disturbances are related to hypoxemia, i.e. reduction of O2-concentration in the blood. The differential diagnosis of hypoxemia includes normoxic, hypoxic and circulatoric disturbances of oxygen supply (cf. Fig. 1). Thus it is necessary to describe a NORMOXIC HYPOXEMIA (anemic or toxemic), a HYPOXIC HYPOXEMIA (decreased O2-concentration caused by a reducted pO2) and an ISCHEMIC HYPOXEMIA (reduction of perfusion). In clinical medicine, O2 supply disturbances are commonly judged by measurement of the pO2. However, hypoxemia (reduction of O2-concentration) is only in part characterized by hypoxia (decrease of pO2). Furthermore the pO2, however, compared to the oxygen concentration is characterized by a tremendous intra- and interindividual range of variation(1,2,3).


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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Friedrich Mertzlufft
    • 1
  • Rolf Zander
    • 1
  1. 1.Department of PhysiologyUniversity of MainzMainzGermany

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