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Elements for Modeling Inert Gas Washout from Heterogeneous Tissues

  • Peter Scheid
  • Michael Meyer
  • Johannes Piiper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 180)

Abstract

Inert gas washout from skeletal muscle has been studied in an attempt at investigating the importance of diffusion and perfusion in tissue gas exchange. The time course of inert gas elimination, following a step decrease in inert gas content of the perfusing blood, typically displays a complex pattern which can be analyzed as a sum of several exponentials with differing amplitudes and rate constants (Kjellmer et al., 1967; Sejrsen and Tonnesen, 1968; Piiper and Meyer, in press). Heterogeneity of blood flow in the tissue has been assumed to be the major reason for this multi-exponential washout (Kjellmer et al., 1967; Sparks and Mohrman, 1977). It is the aim of this study to analyze, on the basis of simplified models, the elements that can explain the multi-component washout kinetics.

Keywords

Axial Diffusion Tritiated Water Washout Curve Series Arrangement Tissue Cylinder 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Peter Scheid
    • 1
  • Michael Meyer
    • 1
  • Johannes Piiper
    • 1
  1. 1.Institut für PhysiologieRuhr-Universität Bochum, Abteilung Physiologie, Max-Planck-Institut für experimentelle MedizinGöttingenGermany

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