Elements for Modeling Inert Gas Washout from Heterogeneous Tissues
Inert gas washout from skeletal muscle has been studied in an attempt at investigating the importance of diffusion and perfusion in tissue gas exchange. The time course of inert gas elimination, following a step decrease in inert gas content of the perfusing blood, typically displays a complex pattern which can be analyzed as a sum of several exponentials with differing amplitudes and rate constants (Kjellmer et al., 1967; Sejrsen and Tonnesen, 1968; Piiper and Meyer, in press). Heterogeneity of blood flow in the tissue has been assumed to be the major reason for this multi-exponential washout (Kjellmer et al., 1967; Sparks and Mohrman, 1977). It is the aim of this study to analyze, on the basis of simplified models, the elements that can explain the multi-component washout kinetics.
KeywordsAxial Diffusion Tritiated Water Washout Curve Series Arrangement Tissue Cylinder
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