Oxygen Supply to the Myocardium

  • N. S. Faithfull
  • W. Erdmann
  • M. Fennema
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 180)


This paper concerns aspects of oxygenation of the myocardium in relation to coronary artery flow and in relation to areas of ischaemic hypoxia. These results were obtained during the course of experiments designed to set up a myocardial ischaemia model and to investigate the effects of haemodilution on myocardial oxygenation. These studies involved the use of various inspired oxygen concentrations (FIO2’s) and cross-clamping of a terminal branch of the left anterior descending coronary artery, (Faithfull et al 1983a). The paper is inevitably somewhat ‘anecdotal’ in nature, but nevertheless does throw some light on the complicated nature of the oxygenation of myocardial tissue.


Left Anterior Descend Intermittant Positive Pressure Ventilation Inspire Oxygen Concentration Coronary Dilation Coronary Artery Flow 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Berne RM and Rubio R. (1969). Acute Coronary Occlusion: Early Changes that Induce Coronary Dilation and the Development of Collateral Circulation. Am J Cardiol, 24:766.CrossRefGoogle Scholar
  2. De Jong JW and Goldstein S (1974) Changes in Coronary Venous Inosine Concentration and Myocardial Wall Thickening during Regional Ischemia in the Pig. Circulat Res 35:111.PubMedCrossRefGoogle Scholar
  3. Erdmann W. (1980) Continuous on-line acquition of tissue p02, tissue perfusion, oxygen diffusion parameters and neuronal activity. In: Kimmich HP (ed.): Monitoring of Vital Parameters during Extra-Corporeal Circulation. Proc. Int. Conf., Nijmegen (1980). Basel, Karger, p73.Google Scholar
  4. Faithfull NS, Fennema M, Essed CE, Erdmann W, Jeekel H and Lapin R. (1983a) Collateral oxygenation of the ischemic myocardium — the effect of viscosity and oxygen carrying fluorocarbons. In: Advances in Blood Substitute Research, Robert B. Bolin, Robert P. Geyer, George J. Nemo, Eds. Alan R. Liss, Inc., New York, p. 229Google Scholar
  5. Faithfull NS, Fennema M, Essed CE, Erdmann W and Lapin R (1983b) Fluoro- carbon mediated changes in oxygen supply in the ischemically hypoxic myocardium — preliminary report. Journal of Bloodless Medicine and Surgery, 1, 23.Google Scholar
  6. Gregg DE. (1963) Physiology of the Coronary Circulation. The George E Brown Memorial Lecture. Circulation, 27:1128.CrossRefGoogle Scholar
  7. Harris SA. (1941). The Spread of Excitation in Turtle, Dog, Cat and Monkey Ventricles. Am J Physiol, 134:319.Google Scholar
  8. Krell W. (1972) Die polarographische Messung des Sauersoffpartialdruckes mit Mikroelektroden. Untersuchung der methodischen Voraussetzungen fuer die Anwendung in vivo. Thesis, University of MainzGoogle Scholar
  9. Marston EL, Barefoot CA and Spencer MP. (1959). Non-Cannulating Measurements of Coronary Blood Flow. Surg. Forum 10:336.Google Scholar
  10. Reves JG, Erdmann W, Mardis M, Karp RB, King M and Lell WA. (1978). Evidence for Existance of Myocardial Steal. In: Silver IA et al. (eds): Oxygen Transport to Tissue, III. New York — London: Plenum Press. p 755.CrossRefGoogle Scholar
  11. Stam H and de Jong JW. (1977). Sephadex-induced Reduction of Coronary Flow in the Isolated Rat Haert: A Model for Ischemic Heart Disease. J Molec Cell Cardiol, 9:633.CrossRefGoogle Scholar
  12. Tillmans H, Ikeda S, Hansen H, Sarma JSM, Fauvel J-M and Bing RJ. (1974). Microcirculation in the Ventricle of the Dog and Turtle. Circulation Res., 34:561.CrossRefGoogle Scholar
  13. Thompson CI, Rubio R and Berne RM. (1980). Changes in Adenosine and Glycogen Phosphorylase Activity during the Cardiac Cycle. Am J Physiol. 238: H389.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • N. S. Faithfull
    • 1
  • W. Erdmann
    • 1
  • M. Fennema
    • 1
  1. 1.Department of AnaesthesiaErasmus UniversityRotterdamThe Netherlands

Personalised recommendations