Oxygen Affinity of Hemoglobin Solutions Modified by Coupling to PLP or NFPLP and the Effects on Tissue Oxygenation
A solution of hemoglobin can be considered as a plasma expander with blood-gas-transportîng activity since It has colloid osmotic as well as O2 and CO2 transport properties. Animal experiments showed that stroma-free hemoglobin solutions can be infused without affecting renal function of the animals (Rabiner et al., 1967). Therefore stroma-free hemoglobin solutions may be potential blood substitutes especially in emergency situations when other sources of compatible blood are lacking.
KeywordsOxygen Affinity Perfusion Time Hemoglobin Solution High Oxygen Affinity Bile Flow Rate
Unable to display preview. Download preview PDF.