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Oxygen Affinity of Hemoglobin Solutions Modified by Coupling to PLP or NFPLP and the Effects on Tissue Oxygenation

  • J. C. Bakker
  • J. v.d. Plas
  • W. K. Bleeker
  • A. de Vries-v.Rossen
  • M. Schoester
  • H. G. J. Brummelhuis
  • J. A. Loos
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 180)

Abstract

A solution of hemoglobin can be considered as a plasma expander with blood-gas-transportîng activity since It has colloid osmotic as well as O2 and CO2 transport properties. Animal experiments showed that stroma-free hemoglobin solutions can be infused without affecting renal function of the animals (Rabiner et al., 1967). Therefore stroma-free hemoglobin solutions may be potential blood substitutes especially in emergency situations when other sources of compatible blood are lacking.

Keywords

Oxygen Affinity Perfusion Time Hemoglobin Solution High Oxygen Affinity Bile Flow Rate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Bakker, J.C., Gortmaker, G.C., Vrolijk, A.C.M. and Offerijns, F.G.J.: Pflügers Arch 362, 21–31 (1976 a).PubMedCrossRefGoogle Scholar
  2. Bakker, J.C., Gortmaker, G.C., Offerijns, F.G.J.: Pflügers Arch 366, 45–52 (1976 b).PubMedCrossRefGoogle Scholar
  3. Benesch, R.E., Benesch, R., Renthal, R.D. and Maeda, N.: Biochemistry 11, 3576–3582 (1972).PubMedCrossRefGoogle Scholar
  4. Benesch, R., Benesch, R.E., Yung, S., Edalji, R.: Biochem. Biophys.Res. Commun. 4,63 1123–1129 (1975).CrossRefGoogle Scholar
  5. Bleeker, W.K., van Rosevelt, R.F., Ufkes, J.G.R., Loos, J.A., van Mourik, I.A. and Bakker, J.C.: J.Lab.Clin.Med. 100, 540–547 (1982).PubMedGoogle Scholar
  6. Dïepenhorst, P., Sprokholt, R., Prins, H.K.: Vox Sang 23, 308–320 (1972).PubMedCrossRefGoogle Scholar
  7. Duvelleroy, M.A., Buckles, R.G., Rosenkaimer, S., Tung, S., Laver, M.B.: J.Appl.Physïol. 28, 227–233 (1970).PubMedGoogle Scholar
  8. Pocker, A. J.: Org.Chem 38, 4295–4299 (1973).CrossRefGoogle Scholar
  9. Rabiner, S.F., Heibert, F., Lopas, H., Friedman, L.H.: J.Exp.Med. 126, 1127–1142 (1967).PubMedCrossRefGoogle Scholar
  10. Sloviter, H.A., Mukherji, B., Benesch, R., Benesch, R.E., Kwong, S.: Fed.Proc. 41, 652 (1982).Google Scholar
  11. Teisseire, B., Lousance, D., Soulard, C., Herigault, R., Teisseire, L., Laurent, D.: Bull.Europ.Physiopath.resp. 11, 837–851 (1975).Google Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • J. C. Bakker
    • 1
  • J. v.d. Plas
    • 1
  • W. K. Bleeker
    • 1
  • A. de Vries-v.Rossen
    • 1
  • M. Schoester
    • 1
  • H. G. J. Brummelhuis
    • 1
  • J. A. Loos
    • 1
  1. 1.Central Laboratory of the Netherlands Red Cross Blood Transfusion ServiceDepartment Development Quality CriteriaAmsterdamThe Netherlands

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