Advertisement

Heterogeneous Oxygenation of Rectal Carcinomas in Humans: A Critical Parameter for Preoperative Irradiation?

  • P. Wendling
  • R. Manz
  • G. Thews
  • P. Vaupel
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 180)

Abstract

The surgical treatment of rectal carcinoma in humans is often combined with irradiation. However, the efficacy of this latter treatment modality is crucially influenced by the oxygenation status of the tumor tissue to be treated. Therefore, the knowledge of the O2 supply to the tumor tissue is a decisive prerequisite for the assessment of the efficiency of radiotherapy.

Keywords

Normal Mucosa Preoperative Irradiation Oxygenation Status Rectal Carcinoma Rectal Adenocarcinoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Grunewald, W.A., and Lübbers, D.W., 1976, Cryophotometry as a method for analyzing the intracapillary HbO2 saturation of organs under different O2 supply conditions, Advan. Exp. Med. Biol., 75: 55.Google Scholar
  2. Mueller- Klieser, W., Vaupel, P., Manz, R., and Schmidseder, R., 1981, Intracapillary oxyhemoglobin saturation of malignant tumors in humans, Int. J. Radiat. Oncol. Biol. Phys., 7: 1397.PubMedCrossRefGoogle Scholar
  3. Mueller- Klieser, W., Vaupel, P., and Manz, R., 1983, Tumour oxygenation under normobaric and hyperbaric conditions, Brit. J. Radiol., in press.Google Scholar
  4. Vaupel, P., 1982, Pathophysiologie der Durchblutung maligner Tumoren, Funktionsanalyse biolog. Systeme, 8: 1101.Google Scholar
  5. Vaupel, P., Grunewald, W.A., Manz, R., and Sowa, W., 1978, Intracapillary HbO2 saturation in tumor tissue of DS- Carcinosarcoma during normoxia, Advan. Exp. Med. Biol., 94: 367.CrossRefGoogle Scholar
  6. Vaupel, P., Manz, R., Müller- Klieser, W., and Grunewald, W.A. , 1979, Intracapillary HbO2 saturation in malignant tumors during normoxia and hyperoxia, Microvasc. Res., 17: 181.PubMedCrossRefGoogle Scholar
  7. Vaupel, P., Otte, J., and Manz, R., 1982, Oxygenation of malignant tumors after localized microwave hyperthermia, Radiat. Environ, Biophys., 20: 289.CrossRefGoogle Scholar
  8. Vaupel, P., Müller- Klieser, W., Manz, R., Wendling, P., Strube, H.D., and Schmidseder, R., 1983, Heterogeneous oxygenation of malignant tumors in humans, Verh. Dtsch. Krebs- Ges., 4: 153.Google Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • P. Wendling
    • 1
  • R. Manz
    • 1
  • G. Thews
    • 1
  • P. Vaupel
    • 1
  1. 1.Dept. of Surgery, and Dept. of Applied PhysiologyUniversity of MainzMainzFed. Rep. Germany

Personalised recommendations