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Distribution of Cerebrocortical Microflow in Normo- and Hypertensive Rats

  • Andras Eke
  • James H. HalseyJr.
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 180)

Abstract

It has been demonstrated by Choki et al. (1977) that rCBF measured by C antipyrine autoradiography was significantly lower after 2 hours of bilateral carotid ligation in the group of spontaneously hypertensive rats than in that of normotensive animals. The hypertensive brain has been found weak as compared to the normotensive in the circulatory adaptation to transient ischemic episodes (Halsey et al., 1980). In search for an explanation for the impaired circulatory adaptation of the hypertensive brain in ischemia, we have studied the intraparenchymal distribution of blood content — as an idex of vascular caliber — and blood flow through cerebrocortical microareas of normotensive (NTR) and spontaneously hypertensive (SHR) rats under normal conditions.

Keywords

Brain Cortex Reflectance Image Hypertensive Group Blood Content Normotensive Group 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Choki, J., Yamaguchi, T., Takeya, Y., Morotomi, Y., Omae, T., 1977, Effect of carotid artery ligation on the regional cerebral blood flow in nonnoterisive and spontaneously hypertensive rats, Stroke, 8:374–379.PubMedCrossRefGoogle Scholar
  2. Choki, J., Yamaguchi, T., Omae, T., 1979 Effect of chronic hypertension on production of ischemia after carotid ligation, Acta Neurol Scand, Suppl 72 60:292–293.Google Scholar
  3. Eke, A., Reflectometric mapping of microregional blood flow and blood volume in the brain cortex, J of CBF and Metabol, 2:41–53.Google Scholar
  4. Halsey, J. H., O’Brien, M., Strong, E., 1980, Amelioration of cerebral ischemia by prior treatment of hypertension, Stroke, 11(3): 235–239.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Andras Eke
    • 1
    • 2
  • James H. HalseyJr.
    • 1
    • 2
  1. 1.Experimental Research DepartmentSemmelweis Medical UniversityBudapestHungary
  2. 2.Department of NeurologyUniversity of AlabamaBiimnghamEngland

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