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Brain Responses to Experimental Oxygen Deficiency in the Mongolian Gerbil

  • A. Mayevsky
  • N. Zarchin
  • B. Tannenbaum
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 180)

Abstract

Cerebral ischemia was investigated in the Mongolian gerbil due to the incompleteness of the Circle of Willis in this desert rodent (for details see ref. 1). Occlusion of the two carotid arteries in the gerbil may lead to complete cerebral ischemia due to the lack of connection between the basilar and carotid circulations. Under unilateral carotid artery occlusion (left or right) the level of ischemia to be developed is dependent upon the degree of connection between the two hemispheres through the arterior part of the Circle of Willis (1, 2). We adopted the gerbil as an experimental animal due to the ease in producing various levels of ischemia (ranging from minimal ischemia up to the complete one) and thus enabling the comparison with another oxygen deficiency insult-hypoxia.

Keywords

Mongolian Gerbil Carotid Artery Occlusion Increase Blood Volume Gerbil Brain Corrected Fluorescence 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • A. Mayevsky
    • 2
  • N. Zarchin
    • 1
  • B. Tannenbaum
    • 1
  1. 1.Dept. of Life SciencesBar Ilan UniversityRamat GanIsrael
  2. 2.Johnson Research FoundationMedical School University of PennsylvaniaPhiladelphiaUSA

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