Cerebral Oxygen Utilization as a Gauge of Brain Energy Metabolism

  • David D. Gilboe
  • Douglas Kintner
  • Janice Yanushka
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 180)


Few studies relate the function of cerebral mitochondria to brain energy metabolism due, in part, to the technical challenge of quantifying energy metabolism. In vivo methods depend on the fact that a change in oxygen supply to the brain results in the blockage of electron transport through the respiratory chain. Consequently, there are detectable changes in NADH1 and cytochrome a/a3 2 concentrations which may be measured optically from the brain surface. Although the equipment is complex and expensive, these methods are advantageous because they provide a less invasive, real time estimate of regional brain redox status. Nevertheless, these data are difficult to equate with either regional ATP turnover or global brain metabolism.


Oxygen Deficit Respiratory Control Ratio High Energy Phosphate Real Time Estimate Brain Energy Metabolism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • David D. Gilboe
    • 1
  • Douglas Kintner
    • 1
  • Janice Yanushka
    • 1
  1. 1.Departments of Neurosurgery and PhysiologyUniversity of Wisconsin Medical SchoolMadisonUSA

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