Effect of Lactate and Pyruvate on Cerebrocortical Microcirculation and NAD/NADH Redox State
In the past, several humoral vasodilatators, like H+, K+, adenosine, lactate, etc., have been suggested being responsible for the coupling between cerebral blood flow CCBF) and metabolism2,10,11,12,13. However, the exact mechanism of coupling is still obscure.The concentration of some of these vasodilatator substances is either not altered (Wahl and Kuschinsky17 and Winn et al.21: H+ and K+ concentrations in the perivascular space of pial arteries and cerebral adenosine content during moderate arterial hypotension) or altered later than CBF (Astrup et al.1 and Morii et al.12: H+, K+ and lactate concentrations during arterial hypoxia), or their increase can not explain entirely the elevation of CBF (Astrup et al.1, Dora et al.7, and Winn et al.21: K+ and adenosine concentrations during arterial hypoxia and epileptic seizures).Because it has been demonstrated that H+, K+, and adenosine are potent dilatators of the pial arteries2,11,16, but such data were not available for lactate, we investigated the vasodilatating efficacy of lactate.
KeywordsCerebral Blood Flow Brain Cortex Pial Artery Cranial Window NADH Fluorescence
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