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Responses of Gerbil Cerebral Unit Activity to Declining Tissue PO2

  • Richard M. Martin
  • James H. HalseyJr.
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 180)

Abstract

Within the central nervous system, microregional differences may exist in tissue oxygen tension due to the variation in such factors as blood flow, capillary density, and rates of tissue respiration. Also, cells located near the venous portion of a capillary should be exposed to a lower oxygen tension than cells at the arterial end as suggested by mathematical modeling based on the Krogh cylinder (Krogh, 1918). Such PO2 differences within brain tissue, in fact, have been demonstrated experimentally (Silver, 1965; Metzger and Heuber, 1977). Taking these variations in tissue PO2 into account, is there then a relative vulnerability of neurons to ischemia or hypoxia? Namely, do those cells normally existing within low PO2 areas suffer the most in that during such an episode of low oxygen availability the PO2 will reach zero in these regions first, or have these low PO2 neurons undergone some adaptive process such that they better tolerate an ischemic or hypoxic insult than cells always normally exposed to a generous oxygen supply? The term “critical PO2” has been used for that PO2 below which cellular dysfunction occurs.

Keywords

Firing Rate Tissue Oxygen Tension Relative Vulnerability Hypoxic Insult Oxygen Microelectrode 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Krogh, A., 1919, The number and distribution of capillaries in muscles with the calculation of the oxygen pressure head necessary for supplying the tissue. J. Physiol. (London), 52:409–415.Google Scholar
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Richard M. Martin
    • 1
  • James H. HalseyJr.
  1. 1.Department of NeurologyUniversity of Alabama in BirminghamBirminghamUSA

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