The Effects of Hypolipidemic Peroxisome Proliferators on the Induction of Sister Chromatid Exchanges

  • Kaija Linnainmaa


A novel class of suspected chemical carcinogens has been recently introduced by Reddy et al. (1). Characteristically, all the agents in the group possess hypolipidemic properties, induce proliferation of peroxisomes in the liver cells, and enhance the peroxisomal ß-oxidation of fatty acids in the liver and kidneys of rodents (2–7). They have been shown to cause liver tumors in experimental animals (1,8–12), but, are not mutagenic in the Ames Salmonella mutagenicity assay (13,14). The induction of peroxisome proliferation was first introduced by the hypolipidemic drug, clofibrate (ethyl-α-p-chlorophenoxyisobutyrate), and some of its structural analogs (15). At present, however, the number of known peroxisome proliferators is about 20, and the group includes several structurally diverse compounds of great industrial importance (e.g., phthalates which are used as plasticiders in the plastic industry) (15). Quite recently, we have also shown that the widely used weed and brush killers, phenoxyacetic acid herbicides 2,4-dichlorophenoxyacetic acid (2,4-D) and 4-chloro-2-methylphenoxyacetic acid (MCPA) induce peroxisome proliferation and hypolipidemia in the liver cells of rodents (16,17). Similar to the previously known peroxisome proliferators, phenoxyacid herbicides are suspected carcinogens (18), even though they are not mutagenic in the Ames Salmonella assay (19).


Sister Chromatid Exchange Structural Chromosome Aberration Phenoxy Acid Acatalasemic Mouse Phenoxy Acid Herbicide 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Kaija Linnainmaa
    • 1
  1. 1.Department of Industrial Hygiene and ToxicologyInstitute of Occupational HealthHelsinki 29Finland

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