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Value and Significance of SCE in Human Leukemia and Cancer

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Sister Chromatid Exchanges

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Abstract

The introduction and refinement of sister chromatid exchange (SCE) techniques generated much enthusiasm, interest, and promise for their application in human neoplasia. In particular, the demonstration of high SCE levels in the cells of Bloom syndrome (BS) patients (1,2), a condition with a very high susceptibility to the development of cancer (primarily lymphoma or leukemia), and the application of SCE as a sensitive and specific index of carcinogenic and/or mutagenic activity (3,4), generated much excitement for the application of SCE studies in human neoplasia. It was hoped that unique changes, akin to those at the chromosome level, would characterize certain malignant conditions and states (5–7). Thus, the general concept was developed that individuals or families with high risk of cancer might show SCE changes characteristic of these groups and that cells involved in certain neoplastic conditions would display unique SCE patterns different from those of normal cells and allow for differential delineation of some neoplastic processes.

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Author information

Authors and Affiliations

  1. Roswell Park Memorial Institute, Buffalo, New York, 14263, USA

    Avery A. Sandberg, Reinhard Becher & Zenon Gibas

Authors
  1. Avery A. Sandberg
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  2. Reinhard Becher
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  3. Zenon Gibas
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Editor information

Editors and Affiliations

  1. Medical Department, Brookhaven National Laboratory, Upton, New York, 11973, USA

    Raymond R. Tice

  2. Council for Research Planning in Biological Sciences, Inc, 1717 Massachusetts Avenue, NW, Washington, DC, 20036-2077, USA

    Alexander Hollaender

  3. Department of Clinical Genetics, Karolinska Hospital, 10401, Stockholm, Sweden

    Bo Lambert

  4. Department of Public Health, Faculty of Medicine, University of Tokyo, Tokyo 113, Japan

    Kanehisa Morimoto

  5. Council for Research Planning in Biological Sciences, Inc, Washington, D.C., USA

    Claire M. Wilson

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© 1984 Plenum Press, New York

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Sandberg, A.A., Becher, R., Gibas, Z. (1984). Value and Significance of SCE in Human Leukemia and Cancer. In: Tice, R.R., Hollaender, A., Lambert, B., Morimoto, K., Wilson, C.M. (eds) Sister Chromatid Exchanges. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4892-4_24

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  • DOI: https://doi.org/10.1007/978-1-4684-4892-4_24

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4894-8

  • Online ISBN: 978-1-4684-4892-4

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