Value and Significance of SCE in Human Leukemia and Cancer
The introduction and refinement of sister chromatid exchange (SCE) techniques generated much enthusiasm, interest, and promise for their application in human neoplasia. In particular, the demonstration of high SCE levels in the cells of Bloom syndrome (BS) patients (1,2), a condition with a very high susceptibility to the development of cancer (primarily lymphoma or leukemia), and the application of SCE as a sensitive and specific index of carcinogenic and/or mutagenic activity (3,4), generated much excitement for the application of SCE studies in human neoplasia. It was hoped that unique changes, akin to those at the chromosome level, would characterize certain malignant conditions and states (5–7). Thus, the general concept was developed that individuals or families with high risk of cancer might show SCE changes characteristic of these groups and that cells involved in certain neoplastic conditions would display unique SCE patterns different from those of normal cells and allow for differential delineation of some neoplastic processes.
KeywordsAcute Lymphocytic Leukemia Bone Marrow Cell Acute Leukemia Sister Chromatid Exchange Aneuploid Cell
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