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Sensitivities of Peripheral Lymphocytes from Healthy Humans and Cancer Patients to Induction of Sister Chromatid Exchanges by Genotoxicants

  • Atsushi Oikawa
  • Setsu Sakai
  • Katsuhiko Horaguchi
  • Ryoko Sugawara
  • Kazunori Sato
  • Jun Tazawa
  • Hiroko Tohda
  • Masakazu Yokoyama
  • Akira Wakui

Abstract

The sister chromatid exchange (SCE) assay is a sensitive method for detection of genotoxic agents (1). On the other hand, the same method detects individuals whose cells are sensitive to any particu lar genotoxicant (2).

Keywords

Healthy Donor Gall Bladder Cancer Stomach Cancer Healthy Human Sister Chromatid Exchange 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Tohda, H., K. Horaguchi, K. Takah ashi, A. Oikawa, and T. Matsu-shima (1980) Epstein-Barr virus-transformed human lymphoblastoid cells for study of sister chromatid exchange and their evaluation as a test system. Cancer Res. 40:4775–4780.PubMedGoogle Scholar
  2. 2.
    Oikawa, A., S. Sakai, K. Horaguchi, and H. Tohda (1983) Sensi tivities of peripheral lymphocytes from healthy humans to induction of sister chromatid exchanges by chemicals. Cancer Res. 43:439–442.PubMedGoogle Scholar
  3. 3.
    Perry, P., and S. Wolff (1974) New Giemsa method for the differential staining of sister chromatids. Nature (Lond.) 251: 156–158.PubMedCrossRefGoogle Scholar
  4. 4.
    Livingston, G.K., L.A. Cannon, D.T. Bishop, P. Johnson, and R.M. Fineman (1983) Sister chromatid exchange: Variation by age, sex, smoking, and breast cancer status. Cancer Genet, and Cytogenet. 9:289–299.CrossRefGoogle Scholar
  5. 5.
    Tohda, H., A. Oikawa, T. Kudo, and T. Tachibana (1978) A greatly simplified method of establishing B-lymphyoblastoid cell lines. Cancer Res. 38:3560–3562.PubMedGoogle Scholar
  6. 6.
    Cleaver, J.E. (1968) Defective repair replication of DNA in xeroderma pigmentosum. Nature (Lond.) 218:652–656.PubMedCrossRefGoogle Scholar
  7. 7.
    Tohda, H., and A. Oikawa (1983) Differential features of sister-chromatid exchange responses to ultraviolet radiation and caffeine in xeroderma pigmentosum lymphoblastoid cell lines. Mutat. Res. 107:387–396.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Atsushi Oikawa
    • 1
  • Setsu Sakai
    • 1
  • Katsuhiko Horaguchi
    • 1
  • Ryoko Sugawara
    • 1
  • Kazunori Sato
    • 1
  • Jun Tazawa
    • 1
  • Hiroko Tohda
    • 1
  • Masakazu Yokoyama
    • 1
  • Akira Wakui
    • 1
  1. 1.Research Institute for Tuberculosis and CancerTohoku UniversitySendai 980Japan

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