Study of Basal Cell Nevus Syndrome Fibroblasts after Treatment with DNA-Damaging Agents

  • H. Nagasawa
  • F. F. Little
  • M. J. Burke
  • E. F. McCone
  • H. S. Targovnik
  • G. L. Chan
  • J. B. Little


Basal cell nevus syndrome (BCNS) is a rare autosomal dominant inherited disorder (1). About 20% of gene carriers develop brain tumors in early childhood. Basal cell nevus syndrome patients are abnormally susceptible to radiation-induced cancer; several patients treated with radio-therapeutic doses have developed large numbers of basal cell tumors in the irradiated field within 6 mo to 3 yr of ex posure (2-5). Featherstone et al. (6) reported that fibroblasts from BCNS patients showed no increased susceptibility to X-ray-induced cell killing; however, GO-irradiated lymphocytes from BCNS patients were found to have a significantly higher level of X-ray-induced chromosomal aberrations (CAs) compared with normal cells. On the other hand, Chan and Little (7) reported that fibroblasts from BCNS patients were slightly hypersensitive to X-ray-induced lethality.


Sister Chromatid Exchange Ataxia Telangiectasia Ataxia Telangiectasia Confluent Culture Human Diploid Fibroblast 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • H. Nagasawa
    • 1
  • F. F. Little
    • 1
  • M. J. Burke
    • 1
  • E. F. McCone
    • 1
  • H. S. Targovnik
    • 1
  • G. L. Chan
    • 1
  • J. B. Little
    • 1
  1. 1.Department of Cancer BiologyHarvard University School of Public HealthBostonUSA

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