Analysis of Sister Chromatid Exchanges in Bloom Syndrome by Use of Endomitotic and Three-Way Differentiation Procedures
Bloom syndrome (BS) is an autosomal recessive disorder characterized by pre-and postnatal growth retardation, a narrow face with dolicocephaly, sun-sensitive eruption of the face, an increased rate of chromosomal instability and sister chromatid exchanges (SCEs), and an increased risk of cancer (1). The most prominent cytogenetic characteristic is an increased rate of SCEs in cells labeled with bromodeoxyuridine (BrdUrd) for 2 cell cycles (2,3), although the exact mechanisms leading to, and the biological significance of, SCEs remain unknown.
KeywordsSister Chromatid Sister Chromatid Exchange Differential Staining Bloom Syndrome Postnatal Growth Retardation
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