Removal and Persistence of SCE-Inducing Damage in Human Lymphocytes in Vitro
The ability to induce sister chromatid exchanges (SCEs) is a well-known property of many DNA-damaging agents (for review see Refs. 20,32). There is no conclusive evidence that any particular type of DNA lesion is more frequently involved in SCE induction than other lesions (e.g., Refs. 3,11,31), although, in general, agents inducing DNA interstrand cross-links appear to be very potent SCE inducers (1,8,13,24).
KeywordsChinese Hamster Ovary Cell Human Lymphocyte Sister Chromatid Exchange Nitrogen Mustard Untreated Control Culture
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