Removal and Persistence of SCE-Inducing Damage in Human Lymphocytes in Vitro

  • Bo Lambert
  • Margareta Sten
  • Dennis Hellgren


The ability to induce sister chromatid exchanges (SCEs) is a well-known property of many DNA-damaging agents (for review see Refs. 20,32). There is no conclusive evidence that any particular type of DNA lesion is more frequently involved in SCE induction than other lesions (e.g., Refs. 3,11,31), although, in general, agents inducing DNA interstrand cross-links appear to be very potent SCE inducers (1,8,13,24).


Chinese Hamster Ovary Cell Human Lymphocyte Sister Chromatid Exchange Nitrogen Mustard Untreated Control Culture 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Bo Lambert
    • 1
  • Margareta Sten
    • 1
  • Dennis Hellgren
    • 1
  1. 1.Department of Clinical GeneticsKarolinska HospitalStockholmSweden

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