Advertisement

Sister Chromatid Exchanges in Mammalian Meiotic Chromosomes

  • J. W. Allen
  • C. W. Gwaltney

Abstract

Very little is known about sister chromatid exchanges (SCEs) in meiotic cells--only that they occur (1) and reveal frequency and distribution patterns apparently unaffected by cross-over (CO) exchange conditions in those cells (2). Unfortunately, the number of studies from which to draw these general conclusions is small due to a variety of methodological difficulties. Only a few organisms have been analyzed for baseline SCEs in meiotic tissue. No information pertaining to the extent or significance of SCE induction by mutagens during meiosis is available.

Keywords

Sister Chromatid Sister Chromatid Exchange Meiotic Chromosome Primary Spermatocyte Meiotic Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    John, B., and K.R. Lewis (1965) The meiotic system. In Protoplasmatalogia VI/F/I, Springer-Verlag, Wien.Google Scholar
  2. 2.
    Tease, C., and G.H. Jones (1979) Analysis of exchanges in differentially stained meiotic chromosomes of Locusta migra-toria after BrdU-substitution and FPG staining. II. Sister chromatid exchanges. Chromosoma 73:75–84.CrossRefGoogle Scholar
  3. 3.
    Beadle, G.W., and S. Emerson (1935) Further studies of cross ing-over in attached-X-chromosomes of Drosophila melanogaster. Genetics 20:192–206.PubMedGoogle Scholar
  4. 4.
    Schwartz, D. (1953) Evidence for sister-strand crossing over in maize. Genetics 38:251–260.PubMedGoogle Scholar
  5. 5.
    Darlington, CD. (1937) Meiosis in diploids and polyploids. In Recent Advances In Cytology, The Blakiston Company, Philadelphia, pp. 85–133.Google Scholar
  6. 6.
    Taylor, J.H., P.S. Woods, and W.L. Hughes (1957) The organi zation and duplication of chromosomes as revealed by autoradiographic studies using tritium-labeled thymidine. Proc. Natl. Acad. Sci., USA 43:122–128.PubMedCrossRefGoogle Scholar
  7. 7.
    Taylor, J.H. (1965) Distribution of tritium-labeled DNA among chromosomes during meiosis. J. Cell Biol. 25:57–67.PubMedCrossRefGoogle Scholar
  8. 8.
    Taylor, J.H. (1984) A brief history of the discovery of sister chromatid exchanges. In Sister Chromatid Exchanges, 25 Years of Experimental Research, R.R. Tice and A. Hollaender, eds., Plenum Press, New York.Google Scholar
  9. 9.
    Latt, S.A. (1973) Microfluorometric detection of DNA replication in human metaphase chromosomes. Proc. Natl. Acad. Sci., USA 70:3395–3399.PubMedCrossRefGoogle Scholar
  10. 10.
    Latt, S.A. (1974) Sister chromatid exchanges, indices of human chromosome damage and repair: Detection by fluorescence and induction by mitomycin C. Proc. Natl. Acad. Sci., USA 71:3162–3166.PubMedCrossRefGoogle Scholar
  11. 11.
    Perry, P., and S. Wolff (1974) New Giemsa method for the differential staining of sister chromatids. Nature (Lond.) 251:156–158.CrossRefGoogle Scholar
  12. 12.
    Perry, P.E. (1980) Chemical mutagens and sister chromatid exchange. In Chemical Mutagens-Principles and Methods for Their Detection, Vol. 6, F. de Serres and A. Hollaender, eds. Plenum Press, New York, pp. 1–39.CrossRefGoogle Scholar
  13. 13.
    Latt, S.A., J. Allen, S.E. Bloom, A. Carrano, E. Falke, D. Kram, E. Schneider, R. Schreck, R. Tice, B. Whitfield, and S. Wolff (1981) Sister chromatid exchanges: A report of the Gene-Tox program. Mutat. Res. 87:17–62.PubMedCrossRefGoogle Scholar
  14. 14.
    Jones, G.H. (1977). A test for early terminalization of chiasraata in diplotene spermatocytes of Schistocerca gregaria. Chromosoma 63:287–294.CrossRefGoogle Scholar
  15. 15.
    Monesi, V. (1962) Autoradiographic study of DNA synthesis and the cell cycle in spermatogonia and spermatocytes of mouse testis using tritiated thymidine. J. Cell Biol. 14:1–18.PubMedCrossRefGoogle Scholar
  16. 16.
    Polani, P.E., J.A. Crolla, and M.J. Seller (1981) An experimental approach to female mammalian meiosis: Differential chromosome labeling and an analysis of chiasmata in the female mouse. In Bioregulators of Reproduction, Vogel and Jagiello, eds. Academic Press, New York, pp. 59–87.CrossRefGoogle Scholar
  17. 17.
    Jones, G.G. ,and C. Tease (1981) Meiotic exchange and analysis by molecular labelling. In Chromosomes Today, Vol. 7, M.D. Bennett, M. Bobrow, and G. Hewitt, eds. George Allen and Unwin, Ltd., London, pp. 114–125.Google Scholar
  18. 18.
    Allen, J.W. (1982) SCE and meiotic crossover exchange in germ cells. In Progress and Topics in Cytogenetics, Vol. 2, Sister Chromatid Exchange, A.A. Sandberg, ed. Alan R. Liss, Inc., New York, pp. 297–311.Google Scholar
  19. 19.
    Allen, J.W. (1979) BrdU-dye characterization of late replication and meiotic recombination in Armenian hamster germ cells. Chromosoma 74:189–207.PubMedCrossRefGoogle Scholar
  20. 20.
    Kriss, J.P., Y. Maruyama, L.A. Tung, S.B. Bond, and L. Revesz (1963) The fate of 5-bromodeoxyuridine, 5-bromodeoxycytidine, and 5-iododeoxycytidine in man. Cancer Res. 23:260–268.PubMedGoogle Scholar
  21. 21.
    Allen, J.W., and S.A. Latt (1976) In vivo BrdU-33258 Hoechst analysis of DNA replication kinetics and sister chromatid exchange formation in mouse somatic and meiotic cells. Chromosoma 58:325–340.PubMedCrossRefGoogle Scholar
  22. 22.
    Kanda, N., and H. Kato (1980) Analysis of crossing over in mouse meiotic cells by BrdU labelling technique. Chromosoma 78:113–121.PubMedCrossRefGoogle Scholar
  23. 23.
    Polani, P.E., J.A. Crolla, M.J. Seller, and F. Moir (1979) Meiotic crossing over exchange in the female mouse visualized by BudR substitution. Nature (Lond.) 278:348–349.CrossRefGoogle Scholar
  24. 24.
    Allen, J .W., C.F. Shuler, and S.A. Latt (1978) Bromodeoxy-uridine tablet methodology for in vivo studies of DNA synthesis. Somatic Cell Genet. 4:393–405.PubMedCrossRefGoogle Scholar
  25. 25.
    Lavappa, K.S., and G. Yerganian (1970) Spermatogonial and meiotic chromosomes of the Armenian hamster, Cricetulus migratorius. Exp. Cell Res. 61:159–172.PubMedCrossRefGoogle Scholar
  26. 26.
    Solari, A.J. (1974) The relationship between chromosomes and axes in the chiasmatic XY pair of the Armenian hamster (Cricetulus migratorius). Chromosoma 48:89–106.PubMedCrossRefGoogle Scholar
  27. 27.
    McFee, A., K.W. Lowe, and San Sebastian, Jr. (1983) Improved sister chromatid differentiation using paraffin-coated bromo-deoxyuridine tablets in mice. Mutat. Res. Letters 119/1:83–88.CrossRefGoogle Scholar
  28. 28.
    Tease, C, and G.H. Jones (1978). Analysis of exchanges in differentially stained meiotic chromosomes of Locusta migra-toria after BrdU-substitution and FPG staining. I. Crossover exchanges in monochiasmate bivalents. Chromosoma 69:163–178.CrossRefGoogle Scholar
  29. 29.
    Moens, P.B. (1966) Segregation of tritium-labeled DNA at meiosis in Chorthippus. Chromosoma 19:277–285.PubMedCrossRefGoogle Scholar
  30. 30.
    Jones, G.H., and T. Craig-Cameron (1969) Analysis of meiotic exchange by tritium autoradiography. Nature (Lond.) 223:946–947.CrossRefGoogle Scholar
  31. 31.
    Craig-Cameron, T.A., and G.G. Jones (1969) The analysis of exchanges in tritium-labelled meiotic chromosomes. I. Schistocerca gregaria. Heredity 25:223–232.CrossRefGoogle Scholar
  32. 32.
    Jones, G.H. (1971) The analysis of exchanges in tritium-labelled meiotic chromosomes. II. Stethophyma grossum. Chromosoma 34:367–382.CrossRefGoogle Scholar
  33. 33.
    Gatti, M., S. Pimpinnelli, and B.S. Baker (1980) Relationships among chromatic! interchanges, sister chromatid exchanges, and meiotic recombination in Drosophila melanogaster. Proc. Natl. Acad. Sci., USA 77:1575–1579.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • J. W. Allen
    • 1
  • C. W. Gwaltney
    • 1
  1. 1.Genetic Toxicology Division Health Effects Research LaboratoryU. S. Environmental Protection AgencyResearch Triangle ParkUSA

Personalised recommendations