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Criteria for the Involvement of Adenosine and Adenine Nucleotides in Nonadrenergic, Noncholinergic Transmission

  • Chapter
Methods Used in Adenosine Research

Abstract

In his synthetic overview of the physiology of synaptic transmission, Eccles (1964) summarized the criteria put forward up to then. Since that time, knowledge of neurohumoral transmission has vastly increased, but Eccles’s criteria still provide a good starting point for an appraisal of data and methods used in research concerning the involvement of “purines” in neurotransmission. However, there is a need to incorporate into these five criteria the significant new concepts concerning neurohumoral transmission that have emerged during the past two decades. Among these are:

  • Feedback regulation to the presynaptic terminal by the released neuro-transmitter or by substances released simultaneously.

  • Histochemical identification of nerves based on the neurotransmitter released.

  • Release of more than one functional neurotransmitter from one nerve terminal.

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Authors and Affiliations

  1. Department of Pharmacology, Central Veterinary Institute, Lelystad, The Netherlands

    Lowie P. Jager

  2. Department of Pharmacology, State University, Groningen, The Netherlands

    Adriaan den Hertog

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  1. Lowie P. Jager
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  2. Adriaan den Hertog
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Editors and Affiliations

  1. University of Auckland, Auckland, New Zealand

    David M. Paton

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Jager, L.P., den Hertog, A. (1985). Criteria for the Involvement of Adenosine and Adenine Nucleotides in Nonadrenergic, Noncholinergic Transmission. In: Paton, D.M. (eds) Methods Used in Adenosine Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4886-3_20

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