Criteria for the Involvement of Adenosine and Adenine Nucleotides in Nonadrenergic, Noncholinergic Transmission

  • Lowie P. Jager
  • Adriaan den Hertog


In his synthetic overview of the physiology of synaptic transmission, Eccles (1964) summarized the criteria put forward up to then. Since that time, knowledge of neurohumoral transmission has vastly increased, but Eccles’s criteria still provide a good starting point for an appraisal of data and methods used in research concerning the involvement of “purines” in neurotransmission. However, there is a need to incorporate into these five criteria the significant new concepts concerning neurohumoral transmission that have emerged during the past two decades. Among these are:
  • Feedback regulation to the presynaptic terminal by the released neuro-transmitter or by substances released simultaneously.

  • Histochemical identification of nerves based on the neurotransmitter released.

  • Release of more than one functional neurotransmitter from one nerve terminal.


Vasoactive Intestinal Polypeptide Adenine Nucleotide Field Stimulation Postsynaptic Action Scorpion Venom 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Lowie P. Jager
    • 1
  • Adriaan den Hertog
    • 2
  1. 1.Department of PharmacologyCentral Veterinary InstituteLelystadThe Netherlands
  2. 2.Department of PharmacologyState UniversityGroningenThe Netherlands

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