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Methods Used to Study the Involvement of Adenosine in the Regulation of Lipolysis

  • Bertil B. Fredholm

Abstract

The evidence that adenosine plays a role in the regulation of adipose tissue circulation and metabolism is impressive. Adipose tissue offers many special advantages when studying intraarterial adenosine effects. It is possible to study relevant phenomena in preparations ranging from cell free systems, via isolated purified cells and intact pieces of white adipose tissue in vitro, to intact tissue perfused in situ. Furthermore, the biochemical steps mediating receptor effects are particularly well delineated in this tissue. The present chapter will, however, neither describe the evidence that adenosine is physiologically important in adipose tissue nor review the evidence regarding the biochemical regulation of lipolysis, but will instead focus on the techniques that may be and have been used in studying the role of adenosine in the regulation of adipose tissue function.

Keywords

Adipose Tissue Adenylate Cyclase Adenosine Deaminase Adenosine Level Endogenous Adenosine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Bertil B. Fredholm
    • 1
  1. 1.Department of PharmacologyKarolinska InstituteStockholmSweden

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