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The Platelet—Fibrinogen Interaction

  • Joel S. Bennett

Abstract

Following the observation that adding ADP to platelet-rich plasma resulted in platelet aggregation (Gaarder et al.,1961), it became apparent that factors in plasma were required for this process to proceed (Born and Cross, 1964). Experiments with washed platelets indicated that, at a minimum, calcium and fibrinogen were necessary (Cross, 1964; McLeanet aL, 1964). Similarly, fibrinogen was needed for platelets to adhere to artificial surfaces such as glass (Zucker and Vroman, 1969). The relevance of these in vitroobservations for physiologic platelet function became apparent from the study of individuals with congenital afibrinogenemia. Afibrinogenemic individuals have barely detectable concentrations of plasma fibrinogen and often have a prolonged bleeding time, indicating a concomitant defect in platelet function (Weiss and Rogers, 1971). The platelet defect is secondary to the deficiency of fibrinogen because the abnormal platelet function can be completely corrected by transfusions of fibrinogen. Further observations that platelets from individuals with Glanzmann’s thrombasthenia do not aggregate (Caen, 1972), adhere to glass (Zucker and Vroman, 1969), or adsorb fibrinogen suggest that fibrinogen and the platelet surface undergo a specific interaction (Bang et al,1972). Until recently, an explanation for the fibrinogen requirement for platelet aggregation was not available. However, the demonstration that platelet stimulation exposes a limited number of fibrinogen receptors on the platelet surface provided the key to understanding the role of fibrinogen in platelet function.

Keywords

Platelet Aggregation Human Platelet Plasma Fibrinogen Platelet Surface Human Fibrinogen 
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© Plenum Press New York and London 1985

Authors and Affiliations

  • Joel S. Bennett
    • 1
  1. 1.Hematology-Oncology Section, Department of MedicineUniversity of Pennsylvania School of MedicinePhiladelphiaUSA

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