Plasma Membrane Receptors and Platelet Response

  • Ernst F. Lüscher


It is slightly more than a hundred years ago that Bizzozero (1882) published his remarkable article on the blood platelets. He and his contemporaries were particularly impressed by the ease with which platelets adhered to vascular lesions and to each other. There is good reason to believe that the formation of a “white thrombus” and of a hemostatic plug by virtue of the formation of tight platelet aggregates must have been common knowledge before the end of the last century. It is rather amazing that the following 50 years were characterized by an almost total disregard of the blood platelets and the revival of interest in them in fact was mainly derived, not from their role in hemostasis and thrombus formation, but from their essential contribution to the intrinsic blood-clotting system. Today we know that platelets, besides their participation in blood coagulation, have a variety of functions including participation in the upkeep of vascular integrity and the provision of a remarkable diversity of materials that are released during their activation and that range from prostaglandins and thromboxane to the contents of their storage organelles with platelet-derived growth factor as a particularly prominent representative. Nonetheless, there is certainly agreement that the formation of the hemostatic plug and of its pathological counterpart, the “white” thrombus, is the most spectacular and, at least at first sight, most important manifestation of platelet activity.


Human Platelet Blood Platelet Receptor Molecule Platelet Membrane Plasma Membrane Receptor 
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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Ernst F. Lüscher
    • 1
  1. 1.Theodor Kocher InstituteUniversity of BerneBerne 9Switzerland

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