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The Role of Calcium in the Transduction of Insulin Action

  • Jay M. McDonald
  • Harrihar A. Pershadsingh

Abstract

The year 1983 has particular significance for progenitors of the role of calcium in neurohumoral action and cell regulation, since it was precisely 100 years earlier that Ringer’s classic paper, describing the vital role of calcium in the generation of mechanical events in the heart, was published.(1) Since then, calcium has been shown to be an essential regulator of a diverse constellation of fundamental intracellular processes.(2–5) A fairly large body of evidence has accumulated over the past 20 years that implies an important role of calcium in the molecular mechanism of action of insulin. Suffice it to say that a reexamination of the role of calcium in the action of insulin is thereby both timely and fitting, especially in view of recent developments in this area. These are the issues that are dealt with in this brief review of some new and interesting findings that may once again reemphasize the importance of calcium and permit its reconsideration as an essential factor in the mechanism of insulin action.

Keywords

Insulin Receptor Insulin Action Calcium Binding Calcium Transport Cytoplasmic Calcium 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Jay M. McDonald
    • 1
  • Harrihar A. Pershadsingh
    • 1
  1. 1.Division of Laboratory Medicine, Departments of Pathology and MedicineWashington University School of MedicineSt. LouisUSA

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